Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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NF-κB signaling in tanycytes mediates inflammation-induced anorexia.
Mareike Böttcher,Helge Müller-Fielitz,Sivaraj Mohana Sundaram,Sarah Gallet,Vanessa Neve,Kiseko Shionoya,Adriano Zager,Ning Quan,Xiaoyu Liu,Ruth Schmidt-Ullrich,Ronny Haenold,Jan Wenzel,Anders Blomqvist,David Engblom,Vincent Prevot,Markus Schwaninger +15 more
TL;DR: Tanycytes form the brain barrier that mediates the anorexic effect of systemic inflammation in the hypothalamus, and the IL-1β-induced anorexia was alleviated whereas the fever response and lethargy response were unchanged.
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The effect of mate tea (Ilex paraguariensis) on metabolic and inflammatory parameters in high-fat diet-fed Wistar rats.
Maria Carolina Borges,Marco Aurélio Ramirez Vinolo,Karina Nakajima,Inar Alvesde De Castro,Deborah Helena Markowicz Bastos,Primavera Borelli,Ricardo Ambrósio Fock,Julio Tirapegui,Rui Curi,Marcelo Macedo Rogero +9 more
TL;DR: The consumption of mate tea had no consistent effect in the inflammatory response of peritoneal macrophages, but reduced cardiometabolic risk markers.
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Cytokines: the yin and yang of vitiligo pathogenesis.
Mala Singh,Ashwin Kotnis,Shahnawaz D. Jadeja,Anushree Mondal,Mohmmad Shoab Mansuri,Rasheedunnisa Begum +5 more
TL;DR: It is emphasized that cytokine imbalance in systemic and skin microenvironment plays a crucial role in vitiligo pathogenesis and has promising potential as therapeutic targets for Vitiligo patients.
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The paradox of overlapping micronutrient risks and benefits obligates risk/benefit analysis
TL;DR: It is proposed that a critical zone of risk/benefit analysis is established for dosages in excess of the upper level to facilitate policy and risk management decision-making and that statutory restriction of vitamin and mineral food supplement dosages should be delayed in the EU until validated and more scientifically rational methodologies are developed.
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Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases
TL;DR: This article reviewed studies that evaluated the involvement of both mTORC1 and 2 in the regulation of macrophage and adipocyte function and their implication in the development of metabolic disease-associated adipose tissue dysfunction.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron,Peter Walter +1 more
TL;DR: Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and lipids.