Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis
Mei Xiang,Pi-Xiao Wang,Aibing Wang,Xiao-Jing Zhang,Yaxing Zhang,Peng Zhang,Mei Fanghua,Chen Manhua,Hongliang Li +8 more
TL;DR: In this paper, the role of TRAF1 in hepatic steatosis and related metabolic disorders was investigated in high fat diet (HFD)-induced and genetic obesity mice.
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Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach
TL;DR: This review reviews intersecting role of obesity-induced ERS, chronic inflammation, insulin resistance, and oxidative stress in the discovery of targeted therapy and highlights the current progress and strategies on therapeutics being explored in preclinical and clinical research to modulate ERS and UPR signaling.
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Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.
TL;DR: In this article, the authors summarize the current evidence that islet inflammation is a feature of type 2 diabetes, and discuss its role with respect to alpha and beta cell compensation and eventual beta cell failure.
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The A2b adenosine receptor modulates glucose homeostasis and obesity.
Hillary Johnston-Cox,Milka Koupenova,Dan Yang,Barbara E. Corkey,Noyan Gokce,Melissa G. Farb,Nathan K. LeBrasseur,Katya Ravid +7 more
TL;DR: The A2bAR is identified as a significant regulator of HFD-induced hallmarks of type 2 diabetes (T2D), thereby pointing to its therapeutic potential.
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Obesity and the risk and prognosis of gallstone disease and pancreatitis.
TL;DR: Therapy in obese patients should take into account the higher prevalence of gallstones, the possibility of more frequent complications and the need for prophylactic treatment with oral ursodeoxycholic acid during weight loss.
References
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