Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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Journal ArticleDOI
Synergistic Role Among Adipose Tissue Hypertrophy, Dyslipidemia, and Systemic Inflammation in the Development of Atherosclerosis
Journal ArticleDOI
Nutrient sensing pathway genes expression dysregulated in patients with T2DM and coronary artery disease.
Esmaeil Rahimi,Amirhossein Ahmadi,Mohammad Ali Boroumand,Bahram M. Soltani,Mehrdad Behmanesh +4 more
TL;DR: The results suggest that the dysregulation of genes involved in nutrient sensing pathway may be associated with the pathogenesis of CAD in patients with T2DM and these genes could be consider as potential biomarkers.
Book ChapterDOI
Effects of Dietary Lipid Intake on Diabetes
Anil K. G. Kadegowda,Liqing Yu +1 more
TL;DR: The effects of total dietary lipid and lipid classes on insulin sensitivity and diabetes risk are reviewed and the molecular mechanisms involved in the onset and progression of diabetes in adipose tissue, liver, muscle, and pancreatic β-cells are described.
Book ChapterDOI
ER Stress and Inflammation
TL;DR: The biology of ER stress-induced inflammation, its role in various diseases, and the possibility of targeting it for therapeutic purposes are discussed.
Book ChapterDOI
mTOR, Autophagy, Aminoacidopathies, and Human Genetic Disorders
TL;DR: The mechanistic target of rapamycin (mTOR) lies at the center of an intricate metabolic signaling hub orchestrating growth, proliferation, and catabolic outcomes such as autophagy and cellular fate as mentioned in this paper.
References
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