Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
More filters
Journal ArticleDOI
Role of endoplasmic reticulum stress and unfolded protein responses in health and disease
TL;DR: Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis cause ER stress, which is involved in causing many diseases inducing apoptosis like osteoporosis, diabetes, inflammatory responses, cancer, neurodegenerative diseases, etc.
Dissertation
Untersuchung der Relevanz unterschiedlicher Asthma-Suszeptibilitätsgene im Modellorganismus Drosophila melanogaster
TL;DR: In der vorliegenden Arbeit wurde die Relevanz der Asthma-Suszeptibilitatsgene ORMDL3, STAT3 and STAT6 im Atemwegsepithel des Modellorganismus Drosophila melanogaster untersucht, eine Einschrankung des zeit¬lichen Aspektes.
Dissertation
Modelling tumourigenesis and the stress response in Drosophila melanogaster
TL;DR: The Drosophila Immune system as a model in Cancer research and its role in quantification of polarity tumour suppressors, and materials and methods, are described.
Associations Between Variants in the NF- κB1 Gene, Alone or in Combination with Saturated Fats, and Anthropometric Traits in Young Adults
TL;DR: The author states that the manuscript aims to provide a history of the field and some of the techniques used in its development, as well as some suggestions for future research, which are currently being considered.
References
More filters
Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron,Peter Walter +1 more
TL;DR: Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and lipids.