Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
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Sex Hormones in Acquired Immunity and Autoimmune Disease.
TL;DR: The role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus is focused on.
Journal ArticleDOI
Autoimmunity and organ damage in systemic lupus erythematosus
TL;DR: Tsokos reviews how the genetic, epigenetic and microbial environments influence innate and adaptive immune cells to drive immunopathology and organ damage in systemic lupus erythematosus.
Journal ArticleDOI
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases
Kübra Bunte,Thomas Beikler +1 more
TL;DR: A review of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL
Journal ArticleDOI
Regulatory T cells in the treatment of disease
TL;DR: The current progress in modulating Treg cells in autoimmune disorders, transplantation and cancer is described to promote antitumour immunity and regression.
Journal ArticleDOI
Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
TL;DR: A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease.
References
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Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling
TL;DR: It is found that lineage-specific deletion of components of the Notch pathway enhanced Treg cell–mediated suppression of type 1 helper T cell (TH1 cell) responses and protected against their TH1 skewing and apoptosis.
Journal ArticleDOI
IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8− IL-17–Producing T Cells
Masayuki Mizui,Tomohiro Koga,Linda A. Lieberman,Jessica Beltran,Nobuya Yoshida,Mark C. Johnson,Roland Tisch,George C. Tsokos +7 more
TL;DR: It is suggested that administration of IL-2 to lupus-prone mice protects against end-organ damage and suppresses inflammation by dually limiting IL-17–producing DN T cells and expanding Treg.
Journal ArticleDOI
Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus.
Anders A. Bengtsson,Gunnar Sturfelt,Christian Lood,Lars Rönnblom,Ronald F van Vollenhoven,Bengt Axelsson,Birgitta Sparre,Helén Tuvesson,Marie Wallén Öhman,Tomas Leanderson +9 more
TL;DR: In this paper, the pharmacokinetics and tolerability of paquinimod were evaluated in a phase Ib double-blind, placebo controlled, dose-ranging study in which cohorts of systemic lupus erythematosus (SLE) patients received daily oral treatment for 12 weeks.
Journal ArticleDOI
HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen
Nainong Li,Dongchang Zhao,Mark Kirschbaum,Chunyan Zhang,Chia-Lei Lin,Ivan Todorov,Fouad Kandeel,Stephen J. Forman,Defu Zeng +8 more
TL;DR: Conditioning with anti-CD3 and SAHA allows induction of chimerism with lower doses of donor BM cells in old nonautoimmune and autoimmune lupus mice and indicates a radiation-free and GVHD preventative regimen with clinical application potential.
Journal ArticleDOI
Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus.
Jacek C Szepietowski,Surasak Nilganuwong,Anna Wozniacka,Annegret Kuhn,Filippa Nyberg,Ronald F van Vollenhoven,Anders A. Bengtsson,Adam Reich,Dick E. de Vries,Bart van Hartingsveldt,Don Robinson,Robert Gordon,Benjamin Hsu +12 more
TL;DR: Treatment with intravenous sirukumab infusions was generally well tolerated in both cutaneous lupus erythematosus patients with mild, stable, active disease and linear pharmacokinetics in CLE and SLE patients was demonstrated.
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