Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Sex Hormones in Acquired Immunity and Autoimmune Disease.
TL;DR: The role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus is focused on.
Journal ArticleDOI
Autoimmunity and organ damage in systemic lupus erythematosus
TL;DR: Tsokos reviews how the genetic, epigenetic and microbial environments influence innate and adaptive immune cells to drive immunopathology and organ damage in systemic lupus erythematosus.
Journal ArticleDOI
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases
Kübra Bunte,Thomas Beikler +1 more
TL;DR: A review of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL
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Regulatory T cells in the treatment of disease
TL;DR: The current progress in modulating Treg cells in autoimmune disorders, transplantation and cancer is described to promote antitumour immunity and regression.
Journal ArticleDOI
Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
TL;DR: A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease.
References
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Journal ArticleDOI
Pathogenesis of human systemic lupus erythematosus: recent advances
José C. Crispín,Stamatis-Nick C. Liossis,Katalin Kis-Toth,Linda A. Lieberman,Vasileios C. Kyttaris,Yuang-Taung Juang,George C. Tsokos +6 more
TL;DR: This work reviews recent findings that deal with genes associated with disease expression, immune cell molecular abnormalities that lead to autoimmune pathology, and the role of hormones and sex chromosomes in the development of disease.
Journal ArticleDOI
Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus.
TL;DR: The observed increase of apoptotic PMNs and macrophages and the poor ability of macrophage from patients with SLE to phagocytose apoptotic bodies may indicate an impaired clearance mechanism, which may be mediated by factors in a patient's serum.
Journal ArticleDOI
A role for sex chromosome complement in the female bias in autoimmune disease.
Deborah L. Smith-Bouvier,Anagha A. Divekar,Manda V. Sasidhar,Sienmi Du,Seema K. Tiwari-Woodruff,Jennifer K. King,Arthur P. Arnold,Ram Singh,Rhonda R. Voskuhl +8 more
TL;DR: This study determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis and pristane-induced lupus.
Journal ArticleDOI
Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial.
TL;DR: IDEC-131 administered at doses ranging 2.5-10.0 mg/kg over 16 weeks was safe and well tolerated in patients with SLE and there were statistically significant improvements from baseline in all groups, including the placebo group.
Journal ArticleDOI
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial
Zhi-Wei Lai,Robert Hanczko,Eduardo Bonilla,Tiffany Caza,Brandon Clair,Adam Bartos,Gabriella Miklossy,John R. Jimah,Edward Doherty,Hajra Tily,Lisa Francis,Ricardo Garcia,Maha Dawood,Jianghong Yu,Irene Ramos,Ioana L. Coman,Stephen V. Faraone,Paul E. Phillips,Andras Perl +18 more
TL;DR: This pilot study suggests that NAC safely improves lupus disease activity by blocking mTOR in T lymphocytes by blocking rapamycin by glutathione in patients with SLE.
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