Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
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Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies.
TL;DR: In this paper , the authors present an update on these T cell abnormalities along with underlying mechanisms and discuss how these advances can be exploited therapeutically for systemic lupus erythematosus (SLE).
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Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature
Camila Farias Amorim,Fernanda O. Novais,Ba T. Nguyen,Maurício T. Nascimento,Maurício T. Nascimento,Jamile Lago,Jamile Lago,Alexsandro S. Lago,Alexsandro S. Lago,Lucas P. Carvalho,Lucas P. Carvalho,Daniel P. Beiting,Phillip Scott +12 more
TL;DR: In this article, the authors performed RNA sequencing (RNA-seq) on the blood of L braziliensis-infected patients and healthy controls to determine whether localized leishmaniasis infection triggers a systemic immune response that may influence the disease.
Journal ArticleDOI
Urine and serum S100A8/A9 and S100A12 associate with active lupus nephritis and may predict response to rituximab treatment.
Jennifer C Davies,Angela Midgley,Emil Carlsson,Sean Joseph Donohue,Ian N. Bruce,Michael W. Beresford,Christian M. Hedrich +6 more
TL;DR: Findings from this study show promise for clinical application of S100 proteins to predict active renal disease in SLE and response to treatment with RTX.
Journal ArticleDOI
Pathological mechanisms of abnormal iron metabolism and mitochondrial dysfunction in systemic lupus erythematosus
TL;DR: In this article, the authors highlight the latest understanding with regards to how patients with systemic lupus erythematosus may be at risk of cellular iron depletion as a result of both absolute and functional iron deficiency.
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BANK1 alters B cell responses and influences the interactions between B cells and induced T regulatory cells in mice with collagen-induced arthritis.
Jie Yang,Jie Ren,Yiming Yang,Juan Sun,Xiaohui Zhou,Shucong Zheng,Dandan Xuan,Yu Xue,Huimin Fan,Jiong Zhang,Hejian Zou,Weiguo Wan,Ning Kong +12 more
TL;DR: Decreased BANK1 expression promotes B cell responses, resulting in an increased antigen presentation ability and autoantibody production that subsequently influences the communication between B cells and iTregs through a cell-contact-dependent and CTLA-4- cytokine-independent mechanism in CIA mice.
References
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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