Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
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The TGF-β/miR-31/CEACAM1-S axis inhibits CD4+CD25+ Treg differentiation in systemic lupus erythematosus
Yanjuan Liu,Yanjuan Liu,Caiyan Li,Yang Yang,Tao Li,Yunfei Xu,Wenqin Zhang,Muyuan Li,Yizhi Xiao,Jie Hu,Ke Liu,Quan Zhen Li,Quan Zhen Li,Ming Gui,Zuo Xiaoxia,Yisha Li,Huali Zhang +16 more
TL;DR: Reduced activity of miR‐31 by TGF‐β, via the inhibition of NF‐ᴋB, acted to inhibit the differentiation of CD4+CD25+ Tregs by directly targeting CEACAM1‐S and to promote autoimmunity.
Journal ArticleDOI
Systemic lupus erythematosus: an expert insight into emerging therapy agents in preclinical and early clinical development.
Milena Tocut,Milena Tocut,Yehuda Shoenfeld,Yehuda Shoenfeld,Yehuda Shoenfeld,Gisele Zandman-Goddard,Gisele Zandman-Goddard +6 more
TL;DR: An extensive literature search via PubMed, Medline, Elsevier Science and Springer Link databases and selected those articles that focus on phase II–III emerging therapies and offer new findings from existing therapies, which reveal breakthrough concepts in SLE treatment are reviewed.
Journal ArticleDOI
Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases.
TL;DR: The properties of these various nanoparticle formulations and the strategies to use them in the treatment of autoimmune diseases are discussed in this article, where the authors discuss the properties of the various nanoparticles formulations.
Journal ArticleDOI
The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens
TL;DR: It is concluded that understanding the precise roles and relationships shared by all these factors that comprise the exposome and identifying early events and root causes of these disorders can help to develop more targeted therapeutic protocols for the management of this worldwide epidemic of autoimmunity.
Journal ArticleDOI
Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus
Yi-Lin Dan,Chan-Na Zhao,Yan-Mei Mao,Qian Wu,Yi-Sheng He,Yu-Qian Hu,Kun Xiang,Xiao-Ke Yang,Napoleon Bellua Sam,Guo-Cui Wu,Hai-Feng Pan +10 more
TL;DR: In this paper, the authors investigated the association of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) gene single-nucleotide polymorphisms with susceptibility and clinical characteristics of systemic lupus erythematosus (SLE).
References
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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