Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Understanding the role of environmental factors in the development of systemic lupus erythematosus
TL;DR: The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use.
Journal ArticleDOI
CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions.
Stephanie A. Amici,Nicholas A. Young,Janiret Narvaez-Miranda,Kyle A. Jablonski,Jesus Arcos,Lucia E. Rosas,Tracey L. Papenfuss,Jordi B. Torrelles,Wael N. Jarjour,Mireia Guerau-de-Arellano +9 more
TL;DR: It is established that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ) inflammatory stimuli, but not with the alternative stimulus, IL-4, which is consistent with an inflammatory marker role for CD38 in human Macrophages and monocytes.
Journal ArticleDOI
Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress.
TL;DR: The progress in the study on the mechanisms underlying the immunomodulatory and regenerative effects of MSCs is reviewed; the medical translation of MCCs is updated, focusing on the registration trials leading to regulatory approvals; and how to improve therapeutic efficacy and safety of M SC applications for future is discussed.
Journal ArticleDOI
The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases.
TL;DR: The possible therapeutic applications of drugs acting on purinergic pathways, which have been entering clinical development, to manage patients suffering from IMIDs are discussed.
Journal ArticleDOI
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
Leonhard X. Heinz,JangEun Lee,Utkarsh Kapoor,Felix Kartnig,Vitaly Sedlyarov,Konstantinos Papakostas,Adrián César-Razquin,Patrick Essletzbichler,Ulrich Goldmann,Adrijana Stefanovic,Johannes W. Bigenzahn,Stefania Scorzoni,Mattia D. Pizzagalli,Ariel Bensimon,André C. Müller,F. James King,Jun Li,Enrico Girardi,M. Lamine Mbow,Charles E. Whitehurst,Manuele Rebsamen,Giulio Superti-Furga,Giulio Superti-Furga +22 more
TL;DR: The identification of TASL as the component that links endolysosomal TLRs to the IRF5 transcription factor via SLC15A4 provides a mechanistic explanation for the involvement of these proteins in systemic lupus erythematosus.
References
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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