Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Journal ArticleDOI
Too much of a good thing: Detrimental effects of interferon.
TL;DR: Either an aberrant response to infection or an inherited genetic disorder that leads to sustained or increased interferon levels can tip the balance towards pathogenesis.
Journal ArticleDOI
Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus
James J. Pestka,Peyman Akbari,Kathryn A. Wierenga,Melissa A. Bates,Kristen N. Gilley,James G. Wagner,Ryan P. Lewandowski,Lichchavi D. Rajasinghe,Preeti S. Chauhan,Adam L. Lock,Quan Zhen Li,Jack R. Harkema +11 more
TL;DR: In this article, the authors showed that dietary supplementation with docosahexaenoic acid (DHA), an ω-3 polyunsaturated fatty acid (PUFA) found in fish oil, prevented inflammation and autoimmune flaring in this novel model, and that DHA supplementation at a human caloric equivalent of 5 g/d was an effective therapeutic regimen for slowing progression of established autoimmunity triggered by the environmental toxicant cSiO2.
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Serum Levels of T Cell Immunoglobulin and Mucin-Domain Containing Molecule 3 in Patients with Systemic Lupus Erythematosus.
Tomoyuki Asano,Naoki Matsuoka,Yuya Fujita,Haruki Matsumoto,Jumpei Temmoku,Makiko Yashiro-Furuya,Shuzo Sato,Eiji Suzuki,Hiroko Kobayashi,Hiroshi Watanabe,Kiyoshi Migita +10 more
TL;DR: Circulating sTIM-3 levels are elevated in SLE patients, and serum sTim- 3 levels are associated with SLE disease activity and SLE-related organ damage, indicating a possible link between the TIM-3/Gal-9 pathway and Sle clinical phenotypes.
Journal ArticleDOI
Hyaluronic Acid Synthesis Contributes to Tissue Damage in Systemic Lupus Erythematosus.
Abel Suárez-Fueyo,Maria Tsokos,Seung Ki Kwok,Kayaho Maeda,Eri Katsuyama,Peter H. Lapchak,George C. Tsokos +6 more
TL;DR: It is shown that administration of hymecromone (4-Methylumbelliferone, 4-MU), an HA synthesis inhibitor, to lupus-prone mice suppressed dramatically l upus-related pathology and suggested the consideration of inhibition of HA synthesis to treat patients.
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Noncanonical immunomodulatory activity of complement regulator C4BP(β-) limits the development of lupus nephritis.
Ana Luque,Inmaculada Serrano,Elia Ripoll,Catarina Malta,M. Gomà,Anna M. Blom,Josep M. Grinyó,Santiago Rodríguez de Córdoba,Joan Torras,Josep M. Aran +9 more
TL;DR: It is shown that C4BP(β-) treatment prevented the development of proteinuria and albuminuria, decreased significantly the formation of anti-dsDNA antibodies and, locally, mitigated renal glomerular IgG and C3 deposition and generation of apoptotic cells, and could be considered for further clinical development in patients with systemic lupus erythematosus.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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