Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Sex Hormones in Acquired Immunity and Autoimmune Disease.
TL;DR: The role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus is focused on.
Journal ArticleDOI
Autoimmunity and organ damage in systemic lupus erythematosus
TL;DR: Tsokos reviews how the genetic, epigenetic and microbial environments influence innate and adaptive immune cells to drive immunopathology and organ damage in systemic lupus erythematosus.
Journal ArticleDOI
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases
Kübra Bunte,Thomas Beikler +1 more
TL;DR: A review of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL
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Regulatory T cells in the treatment of disease
TL;DR: The current progress in modulating Treg cells in autoimmune disorders, transplantation and cancer is described to promote antitumour immunity and regression.
Journal ArticleDOI
Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
TL;DR: A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease.
References
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Journal ArticleDOI
New insights into the immunopathogenesis of systemic lupus erythematosus
TL;DR: Improved understanding of the pathogenesis of SLE is driving a renewed interest in targeted therapy, and researchers are now on the verge of developing targeted immunotherapy directed at treating either specific organ system involvement or specific subsets of patients with SLE.
Journal ArticleDOI
Plasmacytoid Dendritic Cells (Natural Interferon- α/β-Producing Cells) Accumulate in Cutaneous Lupus Erythematosus Lesions
TL;DR: The findings suggested that P-DCs are an important source of IFN-alpha/beta in cutaneous LE lesions and may therefore be of pathogenic importance.
Journal ArticleDOI
MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.
Yuanjia Tang,Xiaobing Luo,Huijuan Cui,Xuming Ni,Min Yuan,Yanzhi Guo,Xinfang Huang,Haibo Zhou,Niek de Vries,Paul P. Tak,Shunle Chen,Nan Shen +11 more
TL;DR: Investigation of the contribution of microRNA-146a, identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus revealed a negative regulator of innate immunity, which provides potential novel strategies for therapeutic intervention.
Journal ArticleDOI
Defective B cell tolerance checkpoints in systemic lupus erythematosus
Sergey Yurasov,Hedda Wardemann,Johanna Hammersen,Makoto Tsuiji,Eric Meffre,Eric Meffre,Virginia Pascual,Michel C. Nussenzweig,Michel C. Nussenzweig +8 more
TL;DR: SLE is associated with abnormal early B cell tolerance, and 25–50% of the mature naive B cells in SLE patients produce self-reactive antibodies even before they participate in immune responses as compared with 5–20% in controls.
Journal ArticleDOI
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
Hui-Chen Hsu,PingAr Yang,John H. Wang,Qi Wu,Riley C. Myers,Jian Chen,John S. Yi,Tanja Guentert,Albert Tousson,Andrea L Stanus,Thuc-vy L. Le,Robin G. Lorenz,Hui Xu,Jay K. Kolls,Robert H. Carter,Robert H. Carter,David D. Chaplin,Robert W. Williams,John D. Mountz,John D. Mountz +19 more
TL;DR: It is demonstrated that autoimmune BXD2 mice express more IL-17 and show spontaneous development of germinal centers (GCs) before they increase production of pathogenic autoantibodies, suggesting a mechanism by which IL- 17 drives autoimmune responses by promoting the formation of spontaneous GCs.
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