Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Adhesion molecules: a way to understand lupus
TL;DR: The role of well-known cellular adhesion molecules as pathogenic factors in disease development as well as disease activity biomarkers are discussed.
Journal ArticleDOI
Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state.
Jian-Hong Zheng,Lei Zhu,Bomiao Ju,Jing Zhang,Jing Luo,Yanhua Wang,Xiaohong Lv,Dan Pu,Lan He,Jing Wang +9 more
TL;DR: In this paper , the association between systemic lupus erythematosus (SLE) flare and immunophenotypes was investigated. But it was still unclear for the association.
Journal ArticleDOI
Systemic erythematous lupus after treatment of multiple sclerosis with alemtuzumab
TL;DR: A patient who was treated with alemtuzumab for relapsing remitting multiple sclerosis remained stable in a follow-up period of over ten years, however, during the follow- up period she developed thyroiditis one year, as well as systemic erythematous lupus seven years after the last alem TZM infusion.
Journal ArticleDOI
Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
TL;DR: In this paper, the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells including B cells, T cells, and macrophages were reviewed and the truncated PTPRO (PTPRO) was observed in hematopoietic cells.
Journal ArticleDOI
A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice
Nicolas Schall,François Daubeuf,Claire Marsol,Patrick Gizzi,Nelly Frossard,Dominique Bonnet,Jean-Luc Galzi,Sylviane Muller +7 more
TL;DR: The authors investigated the capacity of LIT-927 to correct immune alterations in lupus-prone MRL/lpr mice and explored the mechanism of action implemented by this small molecule in this model.
References
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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