Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Strong association of common variants in the miRNA-binding site of NOD2 gene with clinicopathological characteristics and disease activity of systemic lupus erythematosus.
Emran Esmaeilzadeh,Mostafa Saghi,Mehdi Hassani,Saeideh Davar,Behrang Alani,Bahram Pakzad,Sepideh Ghobakhloo,Sharifeh Khosravi,Mehrdad Sabet +8 more
TL;DR: In this paper, the authors assessed the possible association between SNPs rs3135500 and rs3135499 in the NOD2 gene with systemic lupus erythematosus (SLE) risk in the Iranian population.
Posted ContentDOI
Treatment of Murine Lupus with TIGIT-Ig
Shuowu Liu,Lizhu Sun,Chuqi Wang,Yingshu Cui,Yuee Ling,Tian Li,Fangxing Lin,Wenyan Fu,Min Ding,Shuyi Zhang,Changhai Lei,Shi Hu +11 more
TL;DR: It is suggested that among mice with lupus that were treated with the TIGIT-Ig fusion protein, the onset of proteinuria was delayed, serum concentrations of autoantibodies were reduced without a decrease in the total IgG concentrations, and the survival rate was significantly increased compared to those of the controls.
Journal ArticleDOI
Correlations of serum beta 2-microglobulin level with disease activity and renal involvement in patients with systemic lupus erythematosus
Journal ArticleDOI
Polysaccharide mycophenolate-based nanoparticles for enhanced immunosuppression and treatment of immune-mediated inflammatory diseases.
Yuce Li,Yuchen Lou,Yu Chen,Jing Yang,Danqi Li,Biling Jiang,Jiajia Lan,Jingjing Wen,Yangxue Fu,Yamin Zhang,Juan Tao,Jintao Zhu +11 more
TL;DR: In this article, polysaccharide mycophenolate was synthesized by conjugating MPA molecules to dextran and encapsulated extra free MPA molecule to fabricate MPA@Dex-MPA nanoparticles (NPs) for mediating immunosuppression and treatment of IMIDs.
Journal ArticleDOI
SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis
Eri Itotagawa,Yoshihiko Tomofuji,Yasuhiro Kato,Hachirou Konaka,Kohei Tsujimoto,JeongHoon Park,Daiki Nagira,Takehiro Hirayama,Tatsunori Jo,Toru Hirano,Takayoshi Morita,Masayuki Nishide,Sumiyuki Nishida,Yoshihito Shima,Masashi Narazaki,Yukinori Okada,Hyota Takamatsu,Atsushi Kumanogoh +17 more
TL;DR: In this article , the authors identified BAFF-expressing kidney cells using publicly available scRNA-seq data and immunohistological analysis and found that BAFF is expressed in glomerular macrophages and mesangial cells.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
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Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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