Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
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Journal ArticleDOI
AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression
TL;DR: In this paper , the authors examined the regulatory mechanism of the AHR/TET2/NT5E pathway during systemic lupus erythematosus (SLE) progression.
Journal ArticleDOI
Modulation of Mesenchymal Stem Cells-Mediated Adaptive Immune Effectors’ Repertoire in the Recovery of Systemic Lupus Erythematosus
Akram Hoseinzadeh,Zahra Rezaieyazdi,Jalil Tavakol Afshari,Ali-Mohammad Tamadon Morteza Mahmoudi,Sahar Heydari,Reza Moradi,Seyed-Alireza Esmaeili,Mahmoud Mahmoudi +7 more
TL;DR: The ability of allogenic engrafted MSCs in tissue regeneration and resetting immune homeostasis with the provision of a new immunocyte repertoire has been considered simultaneously in lupus, and the wide variety of potential mediators and mechanisms might be linked to the promotion of the immunomodulatory function of MSCS.
Journal ArticleDOI
SLC7A5 expression is up-regulated in peripheral blood T and B lymphocytes of systemic lupus erythematosus patients, associating with renal damage.
Juan Tian,Xiaowei Li,Yirun Jiang,Feng Gao,Bomiao Ju,Jiayue Chen,Wenhua Zhu,Lan He,Liesu Meng,Shemin Lu +9 more
TL;DR: Wang et al. as mentioned in this paper analyzed SLC7A5 mRNA expression of systemic lupus erythematosus (SLE) patients compared to healthy controls using GEO database, and found that it was increased in CD4 + T cells and CD19 + B cells.
Journal ArticleDOI
Recent advances in cutaneous lupus.
TL;DR: Cutaneous lupus erythematosus (CLE) is an inflammatory and autoimmune skin condition that affects patients with systemic lymphoma (SLE) and exists as an isolated entity without associated SLE as mentioned in this paper .
Book ChapterDOI
The role of infections in SLE pathogenesis
TL;DR: Interactions between infections and select lupus genetic polymorphisms influence the specific impact of infectious exposures, and complex interactions between environmental factors and SLE pathogenesis are ongoing.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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