Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Posted ContentDOI
IL-15 enhances functional properties and responses of cytotoxic CD4+CD28− T cells expanded in Systemic lupus erythematosus
Tingting Wang,Laiyou Wei,Shuihui Meng,Wencong Song,Yulan Chen,Heng Li,Qianqian Zhao,Zhen-You Jiang,Dongzhou Liu,Huan Ren,Xiaoping Hong +10 more
TL;DR: In this article , the authors showed that CD4+CD28− T cells with cytotoxic potential are present in systemic lupus erythematosus (SLE) patients.
Dissertation
Low Density Granulocytes (LDG) in the pathogenesis of Systemic Lupus Erythematosus (SLE): Targets for therapy?
TL;DR: Deletion of LDGs may reduce SLE activity to a greater extent since these cells have an increased pro-inflammatory phenotype compared to normal neutrophils, and current literature still remains controversial on the effect of inhibition ofLDGs activity.
Journal ArticleDOI
Speckle tracking echocardiography for the evaluation of left ventricular function in children with systemic lupus erythematosus
TL;DR: STE could be a promising technique in the early detection of subclinical left ventricular dysfunction in children with SLE, and there was no correlation between STE parameters and disease activity.
Book ChapterDOI
Systemic Lupus Erythematosus
TL;DR: SLE remains a disease with significant unmet need, but there is hope that the study of larger, well-characterized cohorts along with further genetic and experimental medicine studies, will lead to new treatments and improved patient outcomes.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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