Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Sex Hormones in Acquired Immunity and Autoimmune Disease.
TL;DR: The role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus is focused on.
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Autoimmunity and organ damage in systemic lupus erythematosus
TL;DR: Tsokos reviews how the genetic, epigenetic and microbial environments influence innate and adaptive immune cells to drive immunopathology and organ damage in systemic lupus erythematosus.
Journal ArticleDOI
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases
Kübra Bunte,Thomas Beikler +1 more
TL;DR: A review of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL
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Regulatory T cells in the treatment of disease
TL;DR: The current progress in modulating Treg cells in autoimmune disorders, transplantation and cancer is described to promote antitumour immunity and regression.
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Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
TL;DR: A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease.
References
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Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4−CD8− Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus
Hiroshi Kato,Andras Perl +1 more
TL;DR: Results indicate that mTORC1 expands IL-4+ DN T and Th17 cells, and contracts Tregs in SLE, and Rapamycin inhibited m TORC1 in T Regs and promoted their expansion.
Journal ArticleDOI
Erratum: Personalized immunomonitoring uncovers molecular networks that stratify lupus patients ((Cell (2016) 165 (551-565))
Romain Banchereau,Seunghee Hong,Brandi L. Cantarel,Nicole Baldwin,Jeanine Baisch,Michelle Edens,Alma-Martina Cepika,Peter Acs,Jacob Turner,Esperanza Anguiano,Parvathi Vinod,Shaheen Khan,Gerlinde Obermoser,Derek Blankenship,Edward K. Wakeland,Lorien Nassi,Alisa Gotte,Marilynn Punaro,Yong-Jun Liu,Jacques Banchereau,Jose Rossello-Urgell,Tracey Wright,Virginia Pascual +22 more
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
Journal ArticleDOI
Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus
Zhi-Wei Lai,Rebecca Borsuk,Ashwini Shadakshari,Jianghong Yu,Maha Dawood,Ricardo Garcia,Lisa Francis,Hajra Tily,Adam Bartos,Stephen V. Faraone,Paul E. Phillips,Andras Perl +11 more
TL;DR: The mechanistic target of rapamycin (mTOR) is recognized as a sensor of mitochondrial dysfunction and effector of T cell lineage development; however, its role in autoimmunity, including systemic lupus erythematosus, remains unclear.
Journal ArticleDOI
Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus.
Suzanne Donnelly,Wendy Roake,Simon Brown,Philip J. Young,Haley B. Naik,Paul Wordsworth,David A. Isenberg,Kenneth B.M. Reid,Paul Eggleton +8 more
TL;DR: Observations indicate that neutrophils from SLE patients have a reduced ability to be recognized and removed by the C1q/calreticulin/CD91-mediated apoptotic pathway, despite the presence of main apoptotic recognition partners.
Journal ArticleDOI
Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies.
Rufei Lu,Rufei Lu,Melissa E. Munroe,Joel M. Guthridge,Krista Bean,Dustin A. Fife,Hua Chen,Samantha Slight-Webb,Michael P. Keith,John B. Harley,Judith A. James,Judith A. James +11 more
TL;DR: It is found that distinct immunological profiles are predictive for individuals who will develop clinical SLE and may be useful for delineating early pathogenesis, discovering therapeutic targets, and designing prevention trials.
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