Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
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TLDR
Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.About:
This article is published in Trends in Molecular Medicine.The article was published on 2017-07-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Immune dysregulation & Autoimmunity.read more
Citations
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Sex Hormones in Acquired Immunity and Autoimmune Disease.
TL;DR: The role of sex hormones particularly estrogen, in the adaptive immune response, in health, and autoimmune disease with an emphasis on systemic lupus erythematosus is focused on.
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Autoimmunity and organ damage in systemic lupus erythematosus
TL;DR: Tsokos reviews how the genetic, epigenetic and microbial environments influence innate and adaptive immune cells to drive immunopathology and organ damage in systemic lupus erythematosus.
Journal ArticleDOI
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases
Kübra Bunte,Thomas Beikler +1 more
TL;DR: A review of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL
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Regulatory T cells in the treatment of disease
TL;DR: The current progress in modulating Treg cells in autoimmune disorders, transplantation and cancer is described to promote antitumour immunity and regression.
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Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
TL;DR: A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease.
References
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Journal ArticleDOI
Update on Biologic Therapies for Systemic Lupus Erythematosus
Helena Hiemisch Lobo Borba,Andreas Funke,Astrid Wiens,Shirley Ramos da Rosa Utiyama,Cássio Marques Perlin,Roberto Pontarolo +5 more
TL;DR: Although many investigational agents exhibited insufficient efficacy or inadequate safety in clinical trials, one of them, belimumab, fulfilled the efficacy and safety regulatory requirements and was approved for the treatment of SLE in Europe and the USA, which confirms that advances in this field are possible.
Journal ArticleDOI
Systemic lupus erythematosus in 2015: Cellular and metabolic requirements of effector T cells.
TL;DR: Key advances in lupus research in 2015 highlight the contribution of T cells to the pathogenesis of the disease and shed light on the regulation and activity of these cells, which suggest several novel therapeutic targets.
Journal ArticleDOI
SLE-associated risk factors affect DC function
TL;DR: This report updates functional implications or pathways in dendritic cells which are putatively important for the development or propagation of SLE based on genetic and functional studies performed in both human and animal models.
Journal ArticleDOI
Why do women get lupus
TL;DR: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which affects predominantly women, causing significant morbidity and mortality, and high doses of estrogen are shown to promote a Th2 cytokine environment and suppression of the Th1 (IL2, TNFα, IFNγ) cytokines by estrogen.
Molecular abnormalities of the B cell in Systemic Lupus Erythematosus are candidates for functional inhibition treatments
TL;DR: In this article, the aberrant phenotype of B cell signaling in patients with systemic lupus erythematosus (SLE) was discussed and small molecules that have recently been recognized to target important steps of the B cell signal transduction pathways with therapeutic implications for SLE.
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