Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Betulinic Acid: Triterpenoid Derivative Induced NADPH-d Expression in the Urinary System with a Possible Renal Protective Role of Nitric Oxide
Soo Yin,Siddiqua Ayesha,Chellasamy Panneerselvam,Adel I. Alalawy,Fahad M. Almutairi,Mohamed Ali Seyed +5 more
TL;DR: This paper showed that BetA exposure induced NADPH-d expression in both kidney and bladder without causing any significant morphological changes in normal healthy cells of any organs in mice, and the expression patterns in both organs of BetA-treated animals tremendously increased (from day 4 until day 12) when compared to controls.
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Triterpenes induced by young apple fruits in response to herbivore attack.
TL;DR: In this paper, the authors investigated apple triterpene acid's antifeedant activity against lepidopteran insect Spodoptera litura but not against apple pests.
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The Effect of Ursolic Acid and Hyperinsulinemia on the Liver and Kidney Function of Alloxan-Induced Diabetic Male Rabbits
TL;DR: In this paper , the effect of extracted and standard ursolic acid in addition to hyperinsulinemia compared to vitamin B complex on the liver and kidney function of alloxan-induced diabetic male rabbits was examined.
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The roots of olive cultivars differing in tolerance to Verticillium dahliae show quantitative differences in phenolic and triterpenic profiles
Martina Cardoni,Lucía Olmo-García,Irene Serrano-García,Alegría Carrasco-Pancorbo,Jesús Mercado-Blanco +4 more
TL;DR: In this article , a comprehensive metabolic profiling of the roots of six olive cultivars differing in their level of tolerance/susceptibility to Verticillium dahliae was addressed, and potential changes in the metabolite profiles due to the presence of the pathogen were also assessed.
References
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Molecular targets of dietary agents for prevention and therapy of cancer
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Oleanolic acid and ursolic acid: Research perspectives
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