Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Inhibition of Organic Anion Transporting Polypeptide 1B1 and 1B3 by Betulinic Acid: Effects of Preincubation and Albumin in the Media.
Yunseok Oh,Yoo-Seong Jeong,Min Soo Kim,Jee Sun Min,Gongmi Ryoo,Ji Eun Park,Yearin Jun,Yoo-Kyung Song,Se-Eun Chun,Songhee Han,Soo Kyung Bae,Suk-Jae Chung,Wooin Lee +12 more
TL;DR: BA is identified as another OATP1B3 inhibitor with preincubation effect and its duration is suggested to be impacted by altered equilibrium of inhibitors between intracellular and extracellular space (e.g., albumin in the media).
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Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs.
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Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer
TL;DR: Encouraging preclinical data support the efficacy of phytochemicals constituent of diet in the prevention and treatment of cancer, but a deeper understanding of their mechanisms of action and better designed clinical trials are urgently needed.
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Incorporation of Pentacyclic Triterpenes into Mitochondrial MembraneStudies on the Interactions in Model 2D Lipid Systems B
TL;DR: In this article, three representatives of naturally occurring pentacyclic triterpenes (PTs) were subjected to comprehensive studies aimed at the analysis of their interactions with phospholipids found naturally in the mitochondrial membrane.
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Mutual prodrugs of 5-fluorouracil: from a classic chemotherapeutic agent to novel potential anticancer drugs
Valeria Ciaffaglione,Maria N. Modica,Valeria Pittalà,Giuseppe Romeo,Loredana Salerno,Sebastiano Intagliata +5 more
TL;DR: In this article, a review describes the progress made over the last ten years in developing 5-fluorouracil-based mutual prodrugs to improve the therapeutic profile and achieve targeted delivery to cancer tissues.
References
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