Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
Reads0
Chats0
TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
More filters
Journal ArticleDOI
Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids
Christelle M. Andre,Sylvain Legay,Amélie Deleruelle,Niels J. Nieuwenhuizen,Matthew Punter,Cyril Brendolise,Janine M. Cooney,Marc Lateur,Jean-Francois Hausman,Yvan Larondelle,William A. Laing +10 more
TL;DR: It is suggested that Md OSC1 and MdOSC5 are key genes in apple fruit triterpene biosynthesis.
Journal ArticleDOI
Synthesis and screening of ursolic acid-benzylidine derivatives as potential anti-cancer agents.
TL;DR: A library of ursolic acid-benzylidine derivatives have been designed and synthesized using Claisen Schmidt condensation of ______ with various aromatic aldehydes in an attempt to develop potent antitumor agents and compound 3b induced apoptosis in HCT-116 cell lines.
Journal ArticleDOI
Olive Tree Leaves—A Source of Valuable Active Compounds
TL;DR: In this paper, a review provides an insight to the principal bioactive components naturally present in olive leaves, and an overview of the existing/proposed methods associated with their analysis, extraction, applications, and stability.
Journal ArticleDOI
Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.
TL;DR: Aminoalkyl substituted derivatives were synthesized starting from glycyrrhetinic acid methyl ester and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay.
Journal ArticleDOI
Phytochemical Profiles of New Red-Fleshed Apple Varieties Compared with Traditional and New White-Fleshed Varieties.
TL;DR: The results showed that the red-fleshed apples contained, in either the flesh or peel, higher amounts of phenolic acids, anthocyanins, dihydrochalcones, and organic acids but a lower amount of flavan-3-ols than the white-fLEShed apples.
References
More filters
Journal ArticleDOI
Molecular targets of dietary agents for prevention and therapy of cancer
TL;DR: Evidence is presented that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways and the active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases.
Journal ArticleDOI
Oleanolic acid and ursolic acid: Research perspectives
TL;DR: Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet.
Journal ArticleDOI
Pharmacological properties of the ubiquitous natural product betulin.
TL;DR: A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti- HIV therapy.
Journal ArticleDOI
Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals
Teris A. van Beek,Paola Montoro +1 more
TL;DR: The chemical analysis and quality control of Ginkgo leaves, extracts, phytopharmaceuticals and some herbal supplements is comprehensively reviewed and the growing literature on pharmacokinetic and fingerprinting studies of Ginkinggo is briefly summarised.
Journal ArticleDOI
Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas).
TL;DR: Data suggest that anthocyanins and ursolic acid purified from C. mas fruits have biological activities that improve certain metabolic parameters associated with diets high in saturated fats and obesity.