Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Journal ArticleDOI
Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation.
Zihui Zhang,Manli Jiang,Xinya Xie,Haixia Yang,Xinfeng Wang,Lei Xiao,Nanping Wang,Nanping Wang +7 more
TL;DR: It is demonstrated that OA improved high glucose-impaired endothelial function via a PPARδ-mediated mechanism and through eNOS/Akt/NO pathway.
Journal ArticleDOI
Oleanolic Acid and Ursolic Acid in Commercial Dried Fruits
TL;DR: In this paper, HPLC analysis of Oleanolic acid and ursolic acid contents in a variety of dried fruits showed that raisins contained higher levels of OA than the other fruits investigated, with green Raisins containing the highest levels (79.0 mg/100 g).
Journal ArticleDOI
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
TL;DR: Preliminary structure-activity relationship analysis for the 3-deoxy triterpene derivatives as GP inhibitors is discussed, and among this series of compounds, 2alpha-hydroxyurs-12-en-28-oic acid exhibited the most potent activity.
Book ChapterDOI
Chapter 28 – Thymus vulgaris
TL;DR: The antiinflammatory, antibacterial, antifungal, antiviral, antioxidant, and antispasmodic properties of the plant have been discussed and the phytochemical composition of T. vulgaris is reported.
Journal ArticleDOI
Quorum quenching activity of pentacyclic triterpenoids leads to inhibition of biofilm formation by Acinetobacter baumannii.
TL;DR: The quorum quenching potential of three pentacyclic triterpenoids, glycyrrhetinic acid (GRA), ursolic acid (UA) and betulinic acid (BA), representing distinct groups of compounds, was evaluated, suggesting the scope for developing novel combinations against the pathogen is widening.
References
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