Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Triterpenes in cancer: significance and their influence
TL;DR: This review highlights the role of triterpene in targeting signaling pathways in cancer and helps the researchers to discover and design efficacious therapeutics agents.
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Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.
Kalpesh R. Patil,Purusottam Mohapatra,Harun M. Patel,Sameer N. Goyal,Shreesh Ojha,Chanakya Nath Kundu,Chandragouda R. Patil +6 more
TL;DR: The results suggest that the IKKβ inhibition is the major mechanism of the PTs-induced NF-κB inhibition.
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Terpenoids as Potential Geroprotectors.
Ekaterina Proshkina,Sergey Plyusnin,Sergey Plyusnin,Tatyana Babak,Ekaterina Lashmanova,Faniya Maganova,Liubov Koval,Liubov Koval,Elena Platonova,Elena Platonova,Mikhail Shaposhnikov,Alexey Moskalev,Alexey Moskalev +12 more
TL;DR: Terpenes and terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases.
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Antibacterial activity of elder (Sambucus nigra L.) flower or berry against hospital pathogens
Caroline Hearst,Graham McCollum,David Nelson,Linda M. Ballard,B. Cherie Millar,Colin E. Goldsmith,Paul J. Rooney,Anne Loughrey,John E. Moore,Juluri R. Rao +9 more
TL;DR: The seminal findings on the major constituents including terpenes identified in native, historically significant herbal medicinal plant Elder (Sambucus nigra L.)flower and elder berry and their concomitant strong antimicrobial effects exhibited on various nosocomial pathogens notably upon methicillin-resistant Staphylococcus aureus MRSA are reported.
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The chemical and biological potential of C ring modified triterpenoids.
TL;DR: It could be shown that C-ring modifications of OA and UA have only a moderate influence onto the cytotoxic activity of the compounds but a significant impact onto the ability to trigger apoptosis in ovarian cancer cells (cell line A2780).
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