Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Non-invasive monitoring of microbial triterpenoid production using nonlinear microscopy techniques
TL;DR: In this paper , the authors show that triterpenoids can be detected and monitored in living yeast cells by combining coherent anti-Stokes Raman scattering (CARS) and second-harmonic-generation (SHG) microscopy techniques.
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Involvement of Mitochondrial Damage and Oxidative Stress in Apoptosis Induced by Betulin Plus Arsenic Trioxide in Neuroblastoma Cells
Kai Yuan Chen,Wei-Lin Hsu,Shih-Wei Hsu,Chao-Hsuan Chen,Kun-Ting Hong,Chia-Wen Tsai,Wen-Shin Chang,Chao Chen,Jen-Sheng Pei,Hsu Tung Lee,Da Tian Bau +10 more
TL;DR: In this article , a combination of As2O3 plus betulin was used to suppress cell viability and induction of apoptosis, which correlated well with elevated reactive oxygen species (ROS) levels.
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Betulinic acid 2,4-dinitrophenylhydrazone derivatives induce caspa- ses activation in A549 lung cancer cells
Leopoldo Clemente Barattoa,Thomas Müllerc,Brás Heleno de Oliveirad,Reinhard Paschkeb,Kranthi Vanchanagirib +4 more
TL;DR: Caspases-3, -8 and -9 activation was assayed in order to contribute to the elucidation of the mechanism of action of these Betulinic acid 2,4-DNPH derivatives.
Book ChapterDOI
Terpenes Behavior in Soil
TL;DR: In this paper , the authors highlighted terpenoids as the most structurally diverse chemical family in the class of secondary metabolites that are part of natural products, since they act out as protectors against herbivores and pathogens.
Posted ContentDOI
Phytochemical profile of eleven peruvian Mentheae. Isolation of ursolic acid from Clinopodium revolutum (Ruiz & Pavon) Govaerts and analysis of the aqueous infusions
TL;DR: In this paper , the profile of secondary metabolites in eleven Mentheae ( Nepetoideae , Lamiaceae ) from Peru by liquid chromatography associated with Orbitrap mass spectrometry, UHPLC-OT-MS is presented.
References
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Journal ArticleDOI
Molecular targets of dietary agents for prevention and therapy of cancer
TL;DR: Evidence is presented that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways and the active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases.
Journal ArticleDOI
Oleanolic acid and ursolic acid: Research perspectives
TL;DR: Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet.
Journal ArticleDOI
Pharmacological properties of the ubiquitous natural product betulin.
TL;DR: A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti- HIV therapy.
Journal ArticleDOI
Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals
Teris A. van Beek,Paola Montoro +1 more
TL;DR: The chemical analysis and quality control of Ginkgo leaves, extracts, phytopharmaceuticals and some herbal supplements is comprehensively reviewed and the growing literature on pharmacokinetic and fingerprinting studies of Ginkinggo is briefly summarised.
Journal ArticleDOI
Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas).
TL;DR: Data suggest that anthocyanins and ursolic acid purified from C. mas fruits have biological activities that improve certain metabolic parameters associated with diets high in saturated fats and obesity.