Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
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Journal ArticleDOI
Variation of ursolic acid content in flowers of ten Iranian pomegranate (Punica granatum L.) cultivars.
Fatemeh Sharifiyan,Seyed Abbas Mirjalili,Mohammad Fazilati,Elahe Poorazizi,Saeed Habibollahi +4 more
TL;DR: UA values obtained from Iranian cultivars of pomegranate flowers are very significant when compared with other sources of UA, and suggested that the Iranian pome granate flowers might be an excellent UA rich source.
Book ChapterDOI
Thymus vulgaris L.: Thyme
TL;DR: The taxonomy, origin, distribution, and cytology of T. vulgaris is presented in this paper, where the authors describe the economical use of the garden thyme and the chemical diversity of its multiple chemotypes.
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A novel strain of pantoea eucrina endophyte of murraya koenigii with squalene cyclase activity
Indu M Nair,K Jayachandran +1 more
TL;DR: The conversion of squalene to the pentacyclic product hopene by the isolate was confirmed by TLC, HPLC, FTIR and GCMS analysis and was reported as an endophyte of Murraya koenigii for the first time.
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The hypoglycaemic effect of oleanonic acid isolated from pilea elizabethae in a rat model
TL;DR: Comparison of the hypoglycaemic effect of R-E2Gii with glibenclamide showed that the isolate was only mildly effective in reducing post-prandial hyperglycaemia, and bio-directed purification of hexane-ethyl acetate extracts revealed oleanonic acid, that may be responsible for the anti-hyperglycaemic properties of this extract.
Journal ArticleDOI
Biophenolic Profile Modulations in Olive Tissues as Affected by Manganese Nutrition
Nikolina Vidović,Igor Pasković,Igor Lukić,Paula Žurga,Valerija Majetić Germek,Kristina Grozić,Marin Cukrov,Šime Marcelić,Dean Ban,Nassima Talhaoui,Igor Palčić,Vedran Rubinić,Smiljana Goreta Ban +12 more
TL;DR: In this paper, the effects of Mn fertilization on the biophenolic profile in the leaves, stems, and roots of the ‘Istarska bjelica’ olive cultivar were examined.
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