Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Book ChapterDOI
Nonantibiotic-Based Therapeutics Targeting Helicobacter pylori : From Nature to the Lab
TL;DR: In this chapter, natural bioactive compounds, such as polyunsaturated fatty acids and triterpenic acids with anti-H.
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Effects of Vasoactive Chinese Herbs on the Endothelial NO System
TL;DR: A pharmacological enhancement of NO production is of therapeutic interest because numerous Chinese medicinal plants, herbal preparations, or isolated compounds thereof have been shown to stimulate endothelial NO production, which is likely to be a contributing mechanism for their therapeutic effects.
Journal ArticleDOI
Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites.
Irene Julca,Daniela Mutwil-Anderwald,Vaishnervi Manoj,Zahra Khan,Soak Kuan Lai,Lay-Kien Yang,Ing Tsyr Beh,Jerzy Michal Dziekan,Yoon Pin Lim,Shen Kiat Lim,Yee Wen Low,Yuen In Lam,Seth Tjia,Yuguang Mu,Qiao Wen Tan,Przemyslaw Nuc,Le Qin Choo,Gillian S. Khew,Loo Shining,Antony Kam,James P. Tam,Zbynek Bozdech,Maximilian Schmidt,Bjoern Usadel,Yoganathan Kanagasundaram,S. Alseekh,Alisdair R. Fernie,Hoi-Yeung Li,Marek Mutwil +28 more
TL;DR: Zhang et al. as discussed by the authors have shown that O. corymbosa extracts are active against breast cancer cell lines and that ursolic acid is responsible for this activity.
Journal ArticleDOI
Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: Implications for colonic secretory function
Ciara M. Fallon,Jessica S. Smyth,Andrew Sieunguyen Quach,Natalia K. Lajczak-McGinley,Aoibhlinn O'Toole,Kim E. Barrett,Helen Sheridan,Stephen J. Keely +7 more
TL;DR: In this paper , the effects of a prototypical PCT, hederagenin (HG), on FXR expression, activity, and antisecretory actions in colonic epithelial cells were investigated.
Dissertation
Function of triterpenes in Arabidopsis thaliana and their anti-inflammatory activities in mammalian hepatoma cells
TL;DR: A new approach for screenings of anti-inflammatory compounds in the context of complex bacterial extracts is provided and first evidence for a function of marneral and thalianol in phytosulfokine-α signaling and a slightly negative influence on plant defense for both triterpenes is delivered.
References
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