Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
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Ursolic Acid and Its Derivatives as Bioactive Agents
TL;DR: This article comprehensively reviews the information that has become available over the last decade with respect to the sources, chemistry, biological potency and clinical trials of ursolic acid and its derivatives as potential therapeutic agents, with a focus on addressing NCDs.
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Betulin and its derivatives as novel compounds with different pharmacological effects
Shayan Amiri,Sanaz Dastghaib,Mazaher Ahmadi,Parvaneh Mehrbod,Forough Khadem,Hamid Behrouj,Mohamad-Reza Aghanoori,Filip Machaj,Mahdi Ghamsari,Jakub Rosik,Andrzej Hudecki,Abbas Afkhami,Mohammad Hashemi,Marek Los,Pooneh Mokarram,Tayyebeh Madrakian,Saeid Ghavami +16 more
TL;DR: This review discusses B and BA structures and derivatives and comprehensively explain their pharmacological effects in relation to various diseases, and discusses the delivery methods, in which these compounds most effectively target different systems.
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Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
TL;DR: The aim of this review is to comprehensively summarise the potential of betulin and betulinic acid, both in vitro and in vivo, including previous studies of anti-cancer activity of the compounds, with listed cancer cell types susceptible to therapy.
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Ursolic acid in health and disease
Dae Yun Seo,Sung Ryul Lee,Jun-Won Heo,Mi-Hyun No,Byoung Doo Rhee,Kyung Soo Ko,Hyo-Bum Kwak,Jin Han +7 more
TL;DR: Recent data on the beneficial effects and possible uses of UA in health and disease managements are summarized.
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Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs
TL;DR: This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects.
References
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Molecular targets of dietary agents for prevention and therapy of cancer
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