Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Evaluation of Some Biological Applications of Pleurotus citrinopileatus and Boletus edulis Fruiting Bodies.
TL;DR: Biological aspects of the methanolic extracts of Pleurotus citrinopileatus and Boletus edulis fruiting bodies showed inhibitory activity against all biological aspects under investigation, with negligible cytotoxicity against regular mouse hepatocytes and Vero cells.
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Chemical constituents from the leaves and twigs of Syzygium tetragonum Wall
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Synthesis of New Betulonic Acid Conjugates with 2-Perfluoroacylcycloalkane-1,3-Diones Using Polymethylenediamine Linkers
TL;DR: In this article, new betulonic acid conjugates were synthesized in high yields by reacting 2-perfluoroacyl-3-chloro-2-cycloalken-1-ones, which were prepared by treating F-containing cyclic β-triketones with oxalylchloride.
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Ursolic acid ameliorates amyloid β-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome
Thomas Pierre,07065086538 +1 more
TL;DR: In this article , the therapeutic potential of Ursolic acid and its underlying molecular mechanisms using a Caenorhabditis elegans transgenic pathological model was investigated, and it was shown that ursolic acid prevented amyloid β-induced proteotoxic stress.
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Efficacy of Ursolic Acid-Enriched Water-Soluble and Not Cytotoxic Nanoparticles against Enterococci.
Anna Maria Schito,Debora Caviglia,Gabriella Piatti,Alessia Zorzoli,Danilo Marimpietri,Guendalina Zuccari,Gian Carlo Schito,Silvana Alfei +7 more
TL;DR: In this article, a water-soluble Ursolic acid (UA)-loaded dendrimer nanoparticles (UA-G4K NPs) with promising physicochemical properties for their clinical applications were developed.
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Oleanolic acid and ursolic acid: Research perspectives
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