Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Oxidation products of betulin: New tracers of abiotic degradation of higher plant material in the environment
Marie Aimee Galeron,Marie Aimee Galeron,John K. Volkman,Jean-François Rontani,Jean-François Rontani +4 more
TL;DR: In this paper, the degradation of Quercus ilex leaves and suspended particulate matter were collected from the Marseille Luminy area and the Rhone River, respectively, and analyzed in order to validate the tracer potential of betulin oxidation products identified during in vitro simulations.
Journal ArticleDOI
Structure and composition of the wax of the date palm, Phoenix dactylifera L., from the septentrional Sahara
TL;DR: The two main classes, n -alkanes and triterpenoids, are involved in formation of the rodlet wax structure, and Fatty acids, aliphatic alcohols and ketones were also identified.
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Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses
M. Twardziok,M. Twardziok,M. Twardziok,David Meierhofer,Stefan T. Börno,Bernd Timmermann,S Jäger,Sengül Boral,Angelika Eggert,Catharina I. Delebinski,Georg Seifert +10 more
TL;DR: Since the combinatory extract viscumTT exerts highly effective pro-apoptotic effects on Ewing Sarcoma cells in vitro, this phytopolychemotherapy could be a promising adjuvant therapeutic option for paediatric patients with Ewing sarcoma.
Journal ArticleDOI
The content of free and esterified triterpenoids of the native marigold (Calendula officinalis) plant and its modifications in in vitro cultures
Bartosz Niżyński,Abdulwadood Shakir Mahmood Alsoufi,Abdulwadood Shakir Mahmood Alsoufi,Cezary Pączkowski,Marek Długosz,Anna Szakiel +5 more
TL;DR: The obtained results confirm the existence of a strong correlation between morphological differentiation and the biosynthesis of plant secondary metabolites, which influences the potential productivity of in vitro cultures.
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Profiling of Phenolic Compounds and Triterpene Acids of Twelve Apple (Malus domestica Borkh.) Cultivars.
Elisabeta-Irina Geana,Corina Teodora Ciucure,Roxana Elena Ionete,Alexandru Ciocârlan,Aculina Aricu,Anton Ficai,Ecaterina Andronescu +6 more
TL;DR: The amounts of two major triterpenes (oleanolic and ursolic acids) and polyphenols (phenolic acids, flavan-3-ols, flavonoids and t-resveratrol) are reported, together with bioactive properties of twelve apple cultivars measured by chromatographic and spectrophotometric methods.
References
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Journal ArticleDOI
Molecular targets of dietary agents for prevention and therapy of cancer
TL;DR: Evidence is presented that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways and the active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases.
Journal ArticleDOI
Oleanolic acid and ursolic acid: Research perspectives
TL;DR: Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet.
Journal ArticleDOI
Pharmacological properties of the ubiquitous natural product betulin.
TL;DR: A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti- HIV therapy.
Journal ArticleDOI
Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals
Teris A. van Beek,Paola Montoro +1 more
TL;DR: The chemical analysis and quality control of Ginkgo leaves, extracts, phytopharmaceuticals and some herbal supplements is comprehensively reviewed and the growing literature on pharmacokinetic and fingerprinting studies of Ginkinggo is briefly summarised.
Journal ArticleDOI
Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas).
TL;DR: Data suggest that anthocyanins and ursolic acid purified from C. mas fruits have biological activities that improve certain metabolic parameters associated with diets high in saturated fats and obesity.