Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
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Reactive Oxygen Species-Mediated Autophagy by Ursolic Acid Inhibits Growth and Metastasis of Esophageal Cancer Cells
Na-Ri Lee,Ruo Yu Meng,So-Young Rah,Hua Jin,Navin Ray,Seong Hun Kim,Byung Hyun Park,Soo Mi Kim +7 more
TL;DR: The data indicate that UA inhibits the growth of ESCC cells by inducing ROS-dependent autophagy, and Diphenyleneiodonium blocked the ROS and UA induced accumulation of LC3-II levels in ES CC cells, suggesting that UA-induced cell death and autophagosome are mediated by ROS.
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A sensitive liquid chromatography-mass spectrometry method for the simultaneous determination in plasma of pentacyclic triterpenes of Olea europaea L.
Estela Giménez,Estela Giménez,M. Emília Juan,M. Emília Juan,Sara Calvo-Melià,Joana M. Planas,Joana M. Planas +6 more
TL;DR: A simple and accurate liquid-liquid extraction followed by LC-QqQ-MS analysis for the simultaneous determination of the main pentacyclic triterpenes from Olea europaea L. in rat plasma verified that the established methodology is appropriate for bioavailability studies.
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Identification and Quantitation of Ursolic and Oleanolic Acids in Ilex aquifolium L. Leaf Extracts Using 13C and 1H-NMR Spectroscopy
TL;DR: 1H-NMR spectroscopy appeared as a powerful tool for a rapid quantitation of biologically active compounds from I. aquifolium after validation of the method (accuracy, precision, linearity, limit of detection and limit of quantitation).
Journal ArticleDOI
Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies.
TL;DR: In this paper, the authors demonstrate the high antitumor potential of systems for delivery of pentacyclic triterpenoids, characterized by six-and five-membered ring structures, are one of the largest class of natural metabolites sourced from the plant kingdom.
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Aloe vera and Streptozotocin-Induced Diabetes Mellitus
TL;DR: In this article , the effects of Aloe vera prescription on streptozotocin-induced diabetes mellitus was reviewed to provide a clear insight into the role of this medicinal plant in several biological functions, such as antioxidant, wound healing, anti-inflammatory, antihyperglycemic, and antihyperlipidemic in diabetic models.
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