Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
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α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats
TL;DR: It is demonstrated that α-amyrin attenuates HFD-induced metabolic syndrome in rats and preserved the hepatic mRNA and protein levels of PPAR-α, which was reduced in HFD group.
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Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses.
Karine Maria Martins Bezerra Carvalho,Tiago Sousa de Melo,Karina Moura de Melo,Ana Luíza Gomes Quinderé,Francisca Tuelly Bandeira de Oliveira,Ana Flávia Seraine Custódio Viana,Paulo Iury Gomes Nunes,Josiane da Silva Quetz,Daniel de Araújo Viana,Armenio André de Carvalho Almeida da Silva,Alexandre Havt,Said Gonçalves da Cruz Fonseca,Mariana Helena Chaves,Vietla Satyanarayana Rao,Flávia A. Santos +14 more
TL;DR: In this article, α,β-amyrin, a triterpenoid mixture from Protium heptaphyllum, was evaluated on high-fat diet-induced obesity in mice.
Journal ArticleDOI
Secondary metabolites, their structural diversity, bioactivity, and ecological functions: An overview
Berhanu M. Abegaz,Henok H. Kinfe +1 more
TL;DR: In this article, the structural diversity of natural products is explored using the scaffold approach focusing on the characteristic carbon frameworks, and a single chart is presented which shows the typical scaffolds of the most important subclasses of alkaloids.
Journal ArticleDOI
Novel oleanolic vinyl boronates: synthesis and antitumor activity
TL;DR: The results show that the incorporation of boron in the oleanolic acid core combined with the presence of amide bonds afforded compounds with desirable biological effects such as apoptosis induction and inhibition of proteasomal activity on tumor cells, which makes them potential templates for further development in the anticancer drug setting.
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Langmuir monolayer studies of the interaction of monoamphiphilic pentacyclic triterpenes with anionic mitochondrial and bacterial membrane phospholipids — Searching for the most active terpene
TL;DR: It turned out that the investigated terpenes interact more favorably with PG molecules as compared to CLs, and α-amyrin exhibited the highest potential to disintegrate the CL containing domains in mitochondrial and bacterial membranes.
References
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