Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Journal ArticleDOI
Triterpenoids Amplify Anti-Tumoral Effects of Mistletoe Extracts on Murine B16.F10 Melanoma In Vivo
Christian M. Struh,Christian M. Struh,Sebastian Jäger,Astrid Kersten,Christoph M. Schempp,Armin Scheffler,Stefan F. Martin +6 more
TL;DR: It is concluded that the addition of solubilized mistletoe triterpenoids to conventional Mistletoe extracts improves the efficacy ofMistletoe treatment and may represent a novel treatment option for malignant melanoma.
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TLC and TLC-MS screening of ursolic, oleanolic and betulinic acids in plant extracts
TL;DR: In this paper, the separation of three triterpenic acids (ursolic, oleanolic and betulinic acid) was achieved on different thin-layer chromatography (TLC) (silica gel 60) and high-performance thin layer chromatography(HPTLC) sorbents using several developing solvents, based on the non-polar diluent n-hexane, and ester (methyl acetate, ethyl acetate) as selector.
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Determination of triterpenic acids in fruits by a novel high performance liquid chromatography method with high sensitivity and specificity.
TL;DR: A novel and interesting pre-column derivatisation method was developed for the analysis of triterpenic acids by high-performance liquid chromatography (HPLC) with fluorescence detection and showed the merits of high sensitivity and less sample consumption.
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Optimization of the derivatization protocol of pentacyclic triterpenes prior to their gas chromatography-mass spectrometry analysis in plant extracts.
TL;DR: A two-level full factorial design to optimize the key derivatization step before the GC-FID and GC-MS analysis of pentacyclic triterpenes was applied and new ones such as maslinic and corosolic acids were identified in apples, sea buckthorn and salvia sclarea.
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Identification of the earliest collagen- and plant-based coatings from Neolithic artefacts (Nahal Hemar cave, Israel).
Caroline Solazzo,Blandine Courel,Jacques Connan,Bart E. van Dongen,H. E. Barden,Kirsty Penkman,Sheila Taylor,Beatrice Demarchi,Pierre Adam,Philippe Schaeffer,Arie Nissenbaum,Ofer Bar-Yosef,Michael Buckley +12 more
TL;DR: The skull residue samples were dominated by benzoate and cinnamate derivatives and triterpenes consistent with a styrax-type resin (Styrax officinalis), thus providing the earliest known evidence of an odoriferous plant resin used in combination with an animal product.
References
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