Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Journal ArticleDOI
Synthesis and Cytotoxic Evaluation of Betulin–Triazole–AZT Hybrids
Dang Thi Tuyet Anh,Le Nhat Thuy Giang,Nguyen Thi Hien,Dinh Thi Cuc,Nguyen Ha Thanh,Nguyen Thi Thu Ha,Nguyen Van Tuyen,Phan Van Kiem +7 more
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Fruits of Vitex Doniana Sweet: Toxicity Profile, Anti-Inflammatory and Antioxidant Activities, and Quantification of One of its Bioactive Constituents Oleanolic Acid
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TL;DR: In this article, the in-vivo anti-inflammatory and antioxidant properties of Vitex doniana were investigated using the carrageenan-induced oedema model in chicks.
Dissertation
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Biological potential of an ethanolic extract from “Mela Rosa Marchigiana” pulp callus culture
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Book ChapterDOI
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