Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.
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TLDR
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark display various pharmacological effects while being devoid of prominent toxicity and are promising leading compounds for the development of new multi-targeting bioactive agents.Abstract:
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.read more
Citations
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Journal ArticleDOI
Determination of triterpenic acids and screening for valuable secondary metabolites in Salvia sp. suspension cultures.
Sibylle Kümmritz,Christiane Haas,Atanas Pavlov,Doris Geib,Roland Ulber,Thomas Bley,Juliane Steingroewer +6 more
TL;DR: These studies provide a method suitable for screening plant and cell culture productivity of triterpenic acids and highlighted interesting co-products of plant cell cultures.
Journal ArticleDOI
Application of Response Surface Methodology for Optimisation of Simultaneous UHPLC-PDA Determination of Oleanolic and Ursolic Acids and Standardisation of Ericaceae Medicinal Plants
TL;DR: A fast and sensitive ultra-high performance liquid chromatography-photodiode array (UHPLC-PDA) method for simultaneous quantification of oleanolic acid and ursolic acid in plant materials was developed in this paper.
Patent
Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof
Jose Carlos Quintela Fernandez,Esther De La Fuente Garcia,Marco Pugliese,Pilar Mancera Aroca,Javier Bustos Santafe,Juan Francisco Espinosa Parrilla,Noemí Virgili Treserres,Blanca Wappenhans Battestini +7 more
TL;DR: In this article, a product comprising a pentacyclic triterpene and hydroxytyrosol or derivatives thereof, uses, and pharmaceutical composition thereof is described, which is related to the present invention.
Journal Article
Quantification of betulinic, oleanolic and ursolic acids as medicinally important triterpenoids in some Thymus species from Iran
TL;DR: In this article, the maximum content of Betulinic acid (BA), oleanolic acid (OA), and ursolic acid were determined in the aerial parts of T. persicus as856.9, 480.6 and 941.7 mg per 100 g dry weight (DW) of plant, respectively while the other Thymus species had an almost negligible amount of these compounds.
Journal Article
In Vivo Biological Evaluation of Polyurethane Nanostructures with Ursolic and Oleanolic Acids on Chemically-induced Skin Carcinogenesis
Camelia Oprean,Florin Borcan,Ioana Zinuca Pavel,Alis Dema,Corina Danciu,Codruta Soica,Cristina Dehelean,Andreea Nicu,Anamaria Ardelean,Mirabela Cristea,Alexandra Ivan,Calin A. Tatu,Florina Bojin +12 more
TL;DR: PU is not a suitable formulation of UA and OA, which have a moderate chemopreventive activity against tumors induced by 7,12-dimethylbenzantracene (DMBA) and 12-O-tetradecanoilphorbol-13-acetate (TPA) application.
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