Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes.
Ekaterina Friebel,Konstantina Kapolou,Susanne Unger,Nicolás Gonzalo Núñez,Sebastian G. Utz,Elisabeth J. Rushing,Luca Regli,Michael Weller,Melanie Greter,Sonia Tugues,Marian Christoph Neidert,Burkhard Becher +11 more
TLDR
This work has mapped the leukocyte landscape of brain tumors using high-dimensional single-cell profiling (CyTOF) and found that tissue-invading TAMs showed a distinctive signature trajectory, revealing tumor-driven instruction along with contrasting lymphocyte activation and exhaustion.About:
This article is published in Cell.The article was published on 2020-06-25 and is currently open access. It has received 329 citations till now. The article focuses on the topics: Glioma & Brain tumor.read more
Citations
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The updated landscape of tumor microenvironment and drug repurposing.
Ming-Zhu Jin,Weilin Jin +1 more
TL;DR: An updated image of TME with emphasis on hypoxic niche, immune microenvironment, metabolism micro environment, acidic niche, innervated niche, and mechanical microenvironment is presented and conventional drugs including aspirin, celecoxib, β-adrenergic antagonist, metformin, and statin are summarized in new antitumor application.
Journal ArticleDOI
Therapeutic Targeting of the Tumor Microenvironment
TL;DR: A comprehensive analysis of the current therapies targeting the tumor microenvironment (TME) is provided in this paper, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
Journal ArticleDOI
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.
Ana Rita Pombo Antunes,Isabelle Scheyltjens,Francesca Lodi,Julie Messiaen,Asier Antoranz,Johnny Duerinck,Daliya Kancheva,Liesbet Martens,Karen De Vlaminck,Hannah Van Hove,Signe Schmidt Kjølner Hansen,Francesca Maria Bosisio,Koen Van der Borght,Steven De Vleeschouwer,Steven De Vleeschouwer,Raf Sciot,Luc Bouwens,M. Verfaillie,Niels Vandamme,Roosmarijn E. Vandenbroucke,Olivier De Wever,Yvan Saeys,Martin Guilliams,Conny Gysemans,Bart Neyns,Frederik De Smet,Diether Lambrechts,Jo A. Van Ginderachter,Kiavash Movahedi +28 more
TL;DR: This article employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence.
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Macrophages as tools and targets in cancer therapy
TL;DR: In this paper , the authors proposed a set of macrophage-targeting strategies that include inhibitors of cytokines and chemokines involved in the recruitment and polarization of tumour-promoting myeloid cells as well as activators of their antitumorigenic and immunostimulating functions.
Journal ArticleDOI
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Nathan Mathewson,Orr Ashenberg,Itay Tirosh,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Sascha Marx,Livnat Jerby-Arnon,Rony Chanoch-Myers,Toshiro Hara,Toshiro Hara,Alyssa R. Richman,Alyssa R. Richman,Yoshinaga Ito,Jason Pyrdol,Mirco Friedrich,Kathrin Schumann,Kathrin Schumann,Michael J. Poitras,Prafulla C. Gokhale,L. Nicolas Gonzalez Castro,Marni E. Shore,Marni E. Shore,Christine M. Hebert,Christine M. Hebert,Brian A. Shaw,Heather L. Cahill,Matthew Drummond,Wubing Zhang,Olamide Olawoyin,Hiroaki Wakimoto,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Priscilla K. Brastianos,X. Shirley Liu,Pamela S. Jones,Daniel P. Cahill,Matthew P. Frosch,David N. Louis,Gordon J. Freeman,Keith L. Ligon,Alexander Marson,Alexander Marson,E. Antonio Chiocca,David A. Reardon,David A. Reardon,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Kai W. Wucherpfennig +49 more
TL;DR: In this paper, single-cell RNA sequencing (RNA-seq) was used to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma.
References
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Discovering Statistics Using SPSS
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
David N. Louis,Arie Perry,Guido Reifenberger,Andreas von Deimling,Dominique Figarella-Branger,Webster K. Cavenee,Hiroko Ohgaki,Otmar D. Wiestler,Paul Kleihues,David W. Ellison +9 more
TL;DR: The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor and is hoped that it will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors.
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