Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease.
TL;DR: It is surmised that the published evidence establishes deficits in synaptic plasticity as a central factor of AD aetiology and potential therapeutic strategies for the treatment of AD are highlighted.
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Regulation of stargazin synaptic trafficking by C-terminal PDZ ligand phosphorylation in bidirectional synaptic plasticity.
TL;DR: J. Neurochem.
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Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2.
Samantha G Ancona Esselmann,Javier Díaz-Alonso,Jonathan M Levy,Michael A. Bemben,Roger A. Nicoll +4 more
TL;DR: The specific AMPAR subunit required for scaling up in CA1 hippocampal pyramidal neurons is determined, and it is found that the GluA2 subunit is both necessary and sufficient, and a critical role for a single amino acid within the membrane-proximal region of the GLUA2 cytoplasmic tail is pointed to.
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Alterations of functional properties of hippocampal networks following repetitive closed-head injury.
TL;DR: Results are consistent with a mechanism in which repetitive closed-head injury affects CA1 hippocampal function by promoting a remodeling of excitatory and inhibitory synaptic inputs leading to impairment in hippocampal-dependent tasks.
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An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction.
TL;DR: This research finds that a recently reported de novo missense mutation in Rac1 prevents Rac1 function and results in a selective reduction in synaptic AMPA receptor function, and prevents the induction of long-term potentiation (LTP), the cellular mechanism underlying learning and memory formation.
References
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The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.