Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Modulation of Agonist Binding to AMPA Receptors by 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine (CX546): Differential Effects across Brain Regions and GluA1–4/Transmembrane AMPA Receptor Regulatory Protein Combinations
TL;DR: The data suggest that variations in physiological drug efficacy, such as the 3-fold difference previously seen in recordings from hippocampus versus thalamus, may be explained by region-specific expression of GluA1–4 as well as TARPs.
Journal ArticleDOI
Role of Site-Specific N-Glycans Expressed on GluA2 in the Regulation of Cell Surface Expression of AMPA-Type Glutamate Receptors
TL;DR: It is demonstrated that the mutant lacking the N-glycan at N370 strongly suppressed the intracellular trafficking of GluA2 from the endoplasmic reticulum (ER) in HEK293 cells, and found that N413 was the main potential site of the HNK-1 epitope that promoted the interaction of GLuA2 with N-cadherin, resulting in enhanced cell surface expression of GLUA2.
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Ca2+-permeable AMPA (α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid) Receptors and Dopamine D1 Receptors Regulate GluA1 Trafficking in Striatal Neurons
David S. Tukey,Edward B. Ziff +1 more
TL;DR: Dopamine and glutamate cooperate in a feed-forward mechanism for synaptic priming whereby an initial stimulus acting independently of voltage-gated conductance increases striatal neuron excitability, facilitating greater neuronal excitation by a subsequent stimulus.
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GluA1 and its PDZ-interaction: A role in experience-dependent behavioral plasticity in the forced swim test
Florian Freudenberg,Verena Marx,Volker Mack,Liliana E. Layer,Matthias Klugmann,Peter H. Seeburg,Rolf Sprengel,Tansu Celikel +7 more
TL;DR: Using an animal model of depression, it is demonstrated that global or hippocampus-selective deletion of GluA1 impairs expression of experience-dependent behavioral despair and link mechanisms of hippocampal synaptic plasticity with behavioral expression of depression.
Journal ArticleDOI
Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica.
Jia Hui Wong,Sangu Muthuraju,Faruque Reza,Mohd Harizal Senik,Jingli Zhang,Nor Aqilah Binti Mohd Yusuf Yeo,Huei Gau Chuang,Hasnan Jaafar,Siti R. Yusof,Habsah Mohamad,Tengku Sifzizul Tengku Muhammad,Nor Hadiani Ismail,Siti Sarwana Husin,Jafri Malin Abdullah +13 more
TL;DR: The results suggest that the enhanced learning and memory observed in animals administered with CA was mainly mediated through increased expression of AMPAR GLUA1 and GluA2 subunits and differential expression of NMDAR GluN2 A and GLUN2B subunits in the hippocampal subfields and EC.
References
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The glutamate receptor ion channels
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.