Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Genetic manipulations of AMPA glutamate receptors in hippocampal synaptic plasticity.
Radu Gugustea,Zhengping Jia +1 more
TL;DR: In this article, a review of studies using various mouse models with genetically altered AMPARs and focus on their roles in basal synaptic transmission, LTP, and LTD at the hippocampal CA1 synapse is presented.
Posted ContentDOI
Intracellular NASPM allows an unambiguous functional measure of GluA2-lacking calcium-permeable AMPA receptor prevalence
TL;DR: In this article, the spider toxin analogue 1-naphthylacetyl spermine (NASPM) was shown to block GluA1-mediated outward currents irrespective of the type of associated AMPAR auxiliary subunit.
Journal ArticleDOI
Long-term memory search across the visual brain.
TL;DR: The author explores how amygdala projections to the visual cortex affect the memory formation and proposes the choice of experimental techniques needed to explain the authors' massive visual memory capacity.
Journal ArticleDOI
Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester
TL;DR: Bicuculline induced GluA2 ubiquitination on the same lysine residues (Lys-870 and Lys-882) in the C-terminal as those elicited by the AMPA treatment is shown, providing the first demonstration of subunit-specific modulation of AMPAR ubiquitinations by the PKC-dependent signalling pathway in mammalian central neurons.
Journal ArticleDOI
The glutamatergic synapse: a complex machinery for information processing
TL;DR: The present review is intended to outline the most important of the glutamatergic mechanisms and their complexity, the understanding of which will be among the most intriguing challenges of future neuroscience.
References
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The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.