Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Posted ContentDOI
A gain‐of‐function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment
Ian D. Coombs,Julie Ziobro,Volodymyr Krotov,Taryn-Leigh Surtees,Stuart G. Cull-Candy,Mark Farrant +5 more
TL;DR: The study suggests that AMPAR gain-of-function (GoF) underlies the effect of the GRIA2 variant in a one-year-old male patient with seizures, and that perampanel may be beneficial in other patients with GRIA GoF variants.
Dissertation
The role of MSK1 in homeostatic plasticity from in vitro to in vivo
TL;DR: The finding of a novel interacting partner associated with clathrin-mediated endocytosis will carve out innovative mechanisms involved in synaptic plasticity.
Proteins and azobenzenes
TL;DR: As a proof of principle, the crystal structure of the ligand-binding domain (LBD) of GluK2 in complex with a photoswitchable agonist has now been solved, which is the first structure showing a membrane receptor bound to a synthetic Photoswitchable ligand.
Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor
TL;DR: In conclusion; during brain development glutamate activated AMPA receptors are very easily lost upon activation rendering these synapses AMPA silent, and Hebbian activity will only temporarily rescue them from AMPA silence, and very low frequency induced depression is related to NMDA receptor dependent LTD.
Dissertation
Homeostatic control of AMPA receptor strength and subunit composition by Polo-like kinase 2
TL;DR: This thesis shows that Plk2 expression was upregulated with chro nic overexcitation, and became targeted to NSF, promoting extensive loss of surface GluR2 expression via increased endocytosis and slowed rec ycling without accompanying synapse loss.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.