Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Peer ReviewDOI
NMDARs regulate the excitatory-inhibitory balance within neural circuits
TL;DR: In this article , the role of NMDAR subunits in the establishment and maintenance of E/I balance was analyzed, which may provide new therapeutic strategies for the recovery of EE imbalance in neurological disorders.
Dissertation
A Three-Molecule Model of Structural Plasticity: the Role of the Rho family GTPases in Local Biochemical Computation in Dendrites
TL;DR: A Three-Molecule Model of Structural Plasticity: the Role of the Rho family GTPases in Local Biochemical Computation in Dendrites by Nathan Gray Hedrick Department of Neurobiology Duke University.
Journal ArticleDOI
RTP801 regulates motor cortex synaptic transmission and learning.
Leticia Pérez-Sisqués,Núria Martín-Flores,Mercè Masana,Júlia Solana-Balaguer,Arnau Llobet,Joan Romaní-Aumedes,Mercè Canal,Genís Campoy-Campos,Esther García-García,Nuria Sánchez-Fernández,Sara Fernández-García,James Gilbert,Manuel J. Rodriguez,Heng-Ye Man,Elena Feinstein,David L. Williamson,David Soto,Xavier Gasull,Jordi Alberch,Cristina Malagelada +19 more
TL;DR: In this article, the role of RTP801/REDD1 in neuronal plasticity and motor learning was investigated in both Parkinson's and Huntington's disease mouse models, and it was shown that RTP-801 knockdown alleviated motor-learning deficits.
Journal ArticleDOI
NMDARs regulate the excitatory-inhibitory balance within neural circuits
TL;DR: In this article , the role of NMDAR subunits in the establishment and maintenance of E/I balance was analyzed, which may provide new therapeutic strategies for the recovery of EE imbalance in neurological disorders.
Journal ArticleDOI
Mutually Dependent Clustering of SynDIG4/PRRT1 and AMPA Receptor Subunits GluA1 and GluA2 in Heterologous Cells and Primary Neurons
TL;DR: Data indicate mutually dependent clustering of SD4 and AMPAR subunits both in COS cells and primary hippocampal neurons, suggesting a mechanism for increased synaptic strength during chemical LTP.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.