Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Synapse-specific expression of calcium-permeable AMPA receptors in neocortical layer 5.
Txomin Lalanne,Txomin Lalanne,Julia Oyrer,Adamo Mancino,Erica Gregor,Andrew J. Chung,Louis Huynh,Sasha Burwell,Jérôme Maheux,Mark Farrant,P. Jesper Sjöström,P. Jesper Sjöström +11 more
TL;DR: The results obtained in the present study help the understanding of pathologies such as stroke and epilepsy that have been associated with disordered regulation of calcium‐permeable AMPA receptors.
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Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors
Tomonari Sumi,Kouji Harada +1 more
TL;DR: This work presents a network model of AMPAR trafficking for adult hippocampal pyramidal neurons, which reproduces both LTP and LTD and indicates that recycling endosomes containing AMPAR are always ready for Syt1/7-dependent exocytosis of AM PAR at peri-synaptic/synaptic membranes.
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Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex.
TL;DR: The published expression of iGluR subunits in the areas and cell types of developing and adult cortex of rat, mouse, carnivore, bovine, monkey, and human as determined with antibody‐ and mRNA‐based techniques is compiled.
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AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.
TL;DR: Re-evaluation of original data in the light of the molecular details regarding AMPARs, conductance changes and plasticity suggests that insertion of high-conductance GluA1 homomers can account for initial findings.
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Post-translational protein modifications in schizophrenia.
TL;DR: A growing body of literature reports glycosylation and lipidation abnormalities in schizophrenia brain as well as in patient peripheral fluids and the functional significance of key glycan and lipid PTMs is explained and current findings associated with abnormal glycosYLation and Lipidation in this illness are summarized.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.