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Open AccessJournal ArticleDOI

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.
About
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.

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Beyond the AMPA receptor: Diverse roles of SynDIG/PRRT brain-specific transmembrane proteins at excitatory synapses.

TL;DR: The SynDIG/proline-rich transmembrane protein (PRRT) family of AMPAR-associated trans-brane proteins as discussed by the authors has been shown to have diverse actions at excitatory synapses that are not limited to the traditional role ascribed to an AMPAR auxiliary factor.
Dissertation

5-HT receptor-mediated modulation of glutamate transmission in the hippocampus and prefrontal cortex and its relation to cognition and depression

TL;DR: The work conducted in this thesis has contributed in understanding the interaction between serotonergic and glutamatergic systems in hippocampal and prefrontal cortex areas, providing novel insights upon mechanism of action of different classes of antidepressants reflected both at the behavioral and molecular level.
Journal ArticleDOI

Psychosocial Crowding Stress-Induced Changes in Synaptic Transmission and Glutamate Receptor Expression in the Rat Frontal Cortex.

TL;DR: In this article, exposure to psychosocial crowding stress (CS) for 3, 7, and 14 days affects glutamate synapse functioning and signal transduction in the frontal cortex (FC) of rats.

Regulation of AMPA receptors by type II-TARPs

Sandra Lemos
TL;DR: In this paper, the modulierten beide Typ-II-TARPs alle AMPARs are unterteilen lassen in TARP-Verhalten.
References
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Journal Article

The glutamate receptor ion channels

TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors

TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity

TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.

TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.
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