Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
Citations
More filters
Journal ArticleDOI
Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2
TL;DR: This study demonstrates that increasing synaptic activity, via treatment with the GABAA receptor antagonist bicuculline, rapidly and robustly induces ubiquitination of the GluA2 AMPAR subunit, and finds that clathrin- and dynamin-dependent endocytosis of AMPARs is required for activity-dependent GLUA2 ubiquitinations.
Journal ArticleDOI
TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function
Marcelo P. Coba,Noboru H. Komiyama,Noboru H. Komiyama,Jess Nithianantharajah,Jess Nithianantharajah,Maksym V. Kopanitsa,Tim Indersmitten,Nathan G. Skene,Ellie J. Tuck,David G. Fricker,Kathryn A. Elsegood,Kathryn A. Elsegood,Lianne E. Stanford,Nurudeen O. Afinowi,Lisa M. Saksida,Timothy J. Bussey,Thomas J. O'Dell,Seth G. N. Grant,Seth G. N. Grant,Seth G. N. Grant +19 more
TL;DR: Data establish TNiK as a critical regulator of cognitive functions and suggest it may play a regulatory role in diseases impacting on its interacting proteins and complexes.
Journal ArticleDOI
AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex.
Hey Kyoung Lee,Alfredo Kirkwood +1 more
TL;DR: A review of AMPAR regulation underlying synaptic plasticity in hippocampus and neocortex using hippocampal CA1 and primary sensory cortices as examples and highlighting the key similarities and functional differences between the two synapses.
Journal ArticleDOI
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus
Pojeong Park,Thomas M. Sanderson,Mascia Amici,Sun-Lim Choi,Zuner A. Bortolotto,Min Zhuo,Bong-Kiun Kaang,Graham L. Collingridge +7 more
TL;DR: It is demonstrated that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is associated specifically with the PKA-dependent form of LTP, and suggested a specific linkage between PKA activation and the rapid synaptic insertion of calcium-permeable AMPA receptors during long-term potentiation.
Journal ArticleDOI
GluA2 (GluR2) Regulates Metabotropic Glutamate Receptor-Dependent Long-Term Depression through N-Cadherin-Dependent and Cofilin-Mediated Actin Reorganization
TL;DR: It is demonstrated that GluA2 regulates metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) through a previously unknown mechanism involving N-cadherin-dependent and cofilin-mediated actin reorganization.
References
More filters
Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.