Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
Min-Yin Li,Wan Ying Miao,Qiu Zi Wu,Shun Ji He,Guoquan Yan,Yanrui Yang,Jia-Jia Liu,Makoto Mark Taketo,Xiang Yu,Xiang Yu +9 more
TL;DR: It is demonstrated that cadherin/catenin complexes stabilize functional synapses and spines through anterograde signaling in the neocortex and provide important molecular evidence for a driving role of presynaptic components in spinogenesis inThe neocortex.
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AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization.
Eric Jacobi,Jakob von Engelhardt +1 more
TL;DR: The influence that AMPAR interacting proteins exert on trafficking and subcellular localization of the receptors by controlling their assembly, ER/Golgi apparatus export, and synaptic anchoring is reviewed.
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Sex Differences in Long-Term Potentiation at Temporoammonic-CA1 Synapses: Potential Implications for Memory Consolidation.
Xiaoqiang Qi,Ke Zhang,Ting Xu,Vitor Nagai Yamaki,Zhisheng Wei,Mingfa Huang,Gregory M. Rose,Xiang Cai,Xiang Cai +8 more
TL;DR: Results suggest that differences in the expression of AMPA and NMDA receptors may affect LTP expression at TA-CA1 synapses in adolescent male and female rats, and thus possibly contribute to the observed sex difference in spatial memory.
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Mechanisms and Role of Dendritic Membrane Trafficking for Long-Term Potentiation.
TL;DR: A modified model where membrane trafficking delivers distinct factors that are required to maintain synapse growth and AMPA receptor incorporation following LTP is proposed, and several fundamental questions are posed that may guide further inquiry into the role of membrane trafficking for synaptic plasticity.
Journal ArticleDOI
Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease
TL;DR: This review will highlight the current state of knowledge regarding functional properties of human stem cell-derived neurons, with a primary focus on pluripotent stem cells.
References
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The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.