Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Dissertation
Intrinsic and synaptic adaptations in neuronal ensembles following recall of appetitive associative memories: investigations in the striatum and prefrontal cortex with the Fos-GFP mouse
TL;DR: By selectively recording from stimuli-activated neurons, this work reveals novel adaptations at the intrinsic and synaptic levels on neuronal ensembles following appetitive learning with both food and drug rewards.
Journal ArticleDOI
The role of post-translational modifications in synaptic AMPA receptor activity.
Elisa Corti,Carlos B. Duarte +1 more
TL;DR: In this paper , the diversity of mechanisms involved in post-translational modification of AMPA receptor subunits, and their impact on the subcellular distribution and synaptic activity of the receptors are discussed.
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Antidepressant Drug Discovery and Development: Mechanism and Drug Design Based on Small Molecules
TL;DR: In this review, the current potential physiological and pathological mechanisms of depression, and the clinical research progresses of candidate drugs as well as the recent advances in small‐molecule drug discovery for potential treatments of depression are systematically summarized.
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Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons
Carlos O. Oueslati Morales,Attila Ignácz,Norbert Bencsik,Zsófia Szíber,Anikó Erika Rátkai,Wolfgang S. Lieb,Stephan A. Eisler,Attila Szűcs,Katalin Schlett,Angelika Hausser +9 more
TL;DR: In this article, the protein kinase D (PKD) family was shown to promote AMPAR endocytosis in primary hippocampal neurons, and pharmacological inhibition of PKD increased synaptic levels of GluA1-containing AMPARs and slowed down their endocytic trafficking.
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The Noonan syndrome-associated D61G variant of the protein tyrosine phosphatase SHP2 prevents synaptic down-scaling.
TL;DR: It is found that synaptic SHP2 levels are temporally regulated during synaptic down-scaling in cultured hippocampal neurons and a molecular mechanism of the Noonan syndrome-associated genetic variant SHp2-D61G that contributes to deficient synaptic down -scaling is revealed.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.