Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
Citations
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Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity
Nathan G. Hedrick,Stephen C. Harward,Charles E. Hall,Hideji Murakoshi,James O. McNamara,Ryohei Yasuda,Ryohei Yasuda +6 more
TL;DR: A three-molecule model of structural long-term potentiation (sLTP) of murine dendritic spines is described, implicating the localized, coincident activation of Rac1, RhoA and Cdc42 as a causal signal of sLTP.
Journal ArticleDOI
Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory.
TL;DR: The acquisition and consolidation of memories of stressful events is modulated by glucocorticoids, a type of corticosteroid hormone that is released in high levels from the adrenal glands after exposure to a stressful event as mentioned in this paper.
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Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment
TL;DR: It is proposed that an effective general strategy for efficient pharmacological intervention could include the identification of specific non‐synaptic targets and the subsequent development of selective pharmacological tools to influence them.
Journal ArticleDOI
Routes, destinations and delays: recent advances in AMPA receptor trafficking
TL;DR: Recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies are reviewed.
Journal ArticleDOI
Recurrent network activity drives striatal synaptogenesis
Yevgenia Kozorovitskiy,Arpiar Saunders,Caroline A. Johnson,Bradford B. Lowell,Bernardo L. Sabatini +4 more
TL;DR: It is found that the balance of activity between the two inhibitory and antagonist pathways in the striatum regulates excitatory innervation of the basal ganglia during development, revealing an important role of positive feedback in driving network maturation.
References
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.