Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Journal ArticleDOI
Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons
Claudia Carvallo,Darwin Contreras,Gonzalo Ugarte,Ricardo Delgado,Floria Pancetti,Carlos Rozas,Ricardo Piña,Luis Constandil,Marc L. Zeise,Bernardo Morales +9 more
TL;DR: In this article, the effects of MPH on performance of preadolescent rats in the Morris Water Maze test were investigated, and the results demonstrated that single and repeated doses with MPH can induce opposite effects at behavioral, cellular, and molecular levels.
Dissertation
The effects of reward devaluation on cue-evoked modulation of sucrose seeking and neuronal ensemble plasticity in nucleus accumbens
TL;DR: Examination of the effects of reward devaluation on ensemble plasticity at the levels of recruitment, excitability, and synaptic physiology in sucrose conditioned Fos-GFP mice that express green fluorescent protein (GFP) in recently activated neurons provides new insights into how updates in the hedonic value of sucrose critically modulates the flexibility of Sucrose seeking and recruitment of ensembles with an altered excitability phenotype in the NAc shell.
Journal ArticleDOI
Functional Roles of the Edited Isoform of GluA2 in GluA2-Containing AMPA Receptor Channels.
Yan Han,Chi-Yen Lin,Li Niu +2 more
TL;DR: The results suggest that glutamate most likely binds to GluA2R with an EC50 of ∼0.5 mM, rather than a non-GluA 2R subunit in a heteromeric AMPA receptor, and binding of two glutamate molecules to the two Glu a2R subunits is sufficient to initiate a conformational change, leading to the opening of the channel.
Book ChapterDOI
Cellular, synaptic, and circuit effects of antibodies in autoimmune CNS synaptopathies.
TL;DR: Understanding the underlying synaptic and circuit mechanisms of patient autoantibody action may enable clinicians to develop diagnostics and therapies unique to each synaptic autoimmunity subtype, thereby improving patient identification and outcomes.
Journal ArticleDOI
Zooming in on AMPA receptor regulation by CaMKII
TL;DR: Insights into the molecular mechanism of synaptic plasticity suggest that AMPA receptor phosphorylation by CaMKII accelerates channel opening and that TARPs preserve this regulation despite the presence of a GluA2 subunit.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.