Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Journal ArticleDOI
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
TL;DR: The crystal structure of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor is reported at 3.6 Å resolution in complex with a competitive antagonist to exploit mechanisms of ion channel activation, desensitization and inhibition by non-competitive antagonists and pore blockers.
Journal ArticleDOI
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani,Wei Lu,Victoria Berge,Ken Nakamura,Bibiana Onoa,Michael K. Lee,Farrukh A. Chaudhry,Roger A. Nicoll,Robert H. Edwards +8 more
TL;DR: It is found that the modest overexpression of alpha-synuclein, in the range predicted for gene multiplication and in the absence of overt toxicity, markedly inhibits neurotransmitter release.
Journal ArticleDOI
AMPARs and Synaptic Plasticity: The Last 25 Years
TL;DR: The progress over the last two and a half decades is reviewed, the future challenges in the field are discussed and a large number of proteins have been identified that regulate this complex process.
Journal ArticleDOI
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Nicola J. Allen,Mariko L. Bennett,Lynette C. Foo,Gordon X. Wang,Chandrani Chakraborty,Stephen J. Smith,Ben A. Barres +6 more
TL;DR: Glypicans is identified as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses.
References
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Kainate Receptor-Mediated Responses in the CA1 Field of Wild-Type and GluR6-Deficient Mice
TL;DR: The results indicate that in CA1 pyramidal cells, distinct subtypes of kainate receptors mediate several functionally antagonistic effects.
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Heteromeric AMPA Receptors Assemble with a Preferred Subunit Stoichiometry and Spatial Arrangement
TL;DR: This work has examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration, and the practical outcome of selective heteromeric assembly is a more homogenous receptor population in vivo.
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Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
Hillel Adesnik,Roger A. Nicoll +1 more
TL;DR: It is concluded that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.
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Adeno-associated virus effectively mediates conditional gene modification in the brain
Brian K. Kaspar,Bryce Vissel,Tasha G. Bengoechea,Steven A. Crone,Lynne Randolph-Moore,Rolf Müller,Eugene P. Brandon,David V. Schaffer,Inder M. Verma,Kuo-Fen Lee,Stephen F. Heinemann,Fred H. Gage +11 more
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Molecular determinants of AMPA receptor subunit assembly.
TL;DR: Progress has been made in understanding the molecular mechanisms underlying subunit assembly and receptor biogenesis in the ER, which determine the size and shape of the postsynaptic response, and are the subject of this review.