Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system
Loïs S. Miraucourt,Michael V. Accardi,Karen E. Asin,Michael K. Pugsley,Michael J. Curtis,Simon Authier +5 more
TL;DR: Glutamatergic synaptic activity and AMPAR biophysical properties in adult animals may be used to characterize test-article-mediated alterations in CNS responses, adding versatility to safety pharmacology assessment of the CNS.
Journal ArticleDOI
Antidepressant-induced increase in GluA2 expression does not translate in changes of AMPA receptor-mediated synaptic transmission at CA3/CA1 synapses in rats
Elisabetta Gerace,L Polenzani,Maurizio Magnani,Elisa Zianni,Gabriella Stocca,Fabrizio Gardoni,Domenico E. Pellegrini-Giampietro,Renato Corradetti +7 more
TL;DR: In this article , the effect of trazodone and paroxetine on the expression of AMPAR subunits in male wistar rat hippocampus and whether these drugs produced a parallel facilitation of field excitatory postsynaptic potentials (fEPSP) responses evoked by activation of CA3/CA1 synapses in dorsal hippocampal slices.
Dissertation
Estudi de dos mecanismes moleculars implicats en l’expressió local d’mRNAs en plasticitat sinàptica
TL;DR: La disminucio dels nivells of KIS compromet el desenvolupament de les espines dendritiques, altera les dinamiques del citoesquelet d’actina i disminueix the capacitat de resposta postsinaptica.
Journal ArticleDOI
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Juan Gu,Xin Tian,Wei Wang,Qin Yang,Peijia Lin,Yuanlin Ma,Yan Xiong,Demei Xu,Yanke Zhang,Yong Yang,Shanshan Lu,Zijun Lin,Jing Luo,Fei Xiao,Xuefeng Wang +14 more
TL;DR: The results suggest that cGKII plays a key role in seizure activity and could be a potential therapeutic target for epilepsy in patients with temporal lobe epilepsy and in a pilocarpine-induced rat model.
The Regulation of Extracellular Amyloid-β Levels by Ionotropic Glutamatergic Transmission in an Alzheimer’s Disease Mouse Model
TL;DR: This paper presents a meta-analysis of the regulation of Amyloid-β Levels through Extracellular Signal-Regulated Kinase in an Alzheimer’s Disease Mouse Model using a model derived from the AD Mouse Model.
References
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The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.