Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
Citations
More filters
Journal ArticleDOI
Tuning hippocampal synapses by stress-hormones: Relevance for emotional memory formation
Hui Xiong,Harm J. Krugers +1 more
TL;DR: How catecholamines and glucocorticoids regulate synaptic function is summarized and how these effects may contribute to acquisition and storage of emotional information is discussed.
Journal ArticleDOI
Input‐specific regulation of hippocampal circuit maturation by non‐muscle myosin IIB
Emin D. Ozkan,Massimiliano Aceti,Thomas K. Creson,Camilo Rojas,Christopher Hubbs,Megan N. McGuire,Priyanka P. Kakad,Courtney A. Miller,Gavin Rumbaugh +8 more
TL;DR: Disruption of in vivo expression of Myh9 and/or Myh10 in developing hippocampal neurons is disrupted to determine how these motors contribute to circuit maturation in this brain area important for cognition, and data indicate that Myosin IIB is a key molecular factor that guides input‐specific circuitmaturation in the developing hippocampus.
Journal ArticleDOI
Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice.
Daria Camera,Harold A. Coleman,Helena C. Parkington,Trisha A. Jenkins,David V. Pow,Natasha A. Boase,Sharad Kumar,Philip Poronnik,Philip Poronnik +8 more
TL;DR: It is indicated that reducing Nedd4 protein by 50% significantly impairs LTP and long-term memory thereby demonstrating an important role for Nedd 4 in these processes.
Journal ArticleDOI
The AMPA Receptor Subunit GluA1 is Required for CA1 Hippocampal Long-Term Potentiation but is not Essential for Synaptic Transmission
TL;DR: It is found that LTP was absent in neurons lacking GluA1, induced either by pairing or by a theta-burst pairing protocol previously shown to induce LTP in GLUA1 knock-out mice, and the results indicate that Glu a2 homomers can mediate synaptic transmission and can compensate for loss of Glu A1.
Journal ArticleDOI
IL-1β reduces GluA1 phosphorylation and its surface expression during memory reconsolidation and α-melanocyte-stimulating hormone can modulate these effects.
TL;DR: The results demonstrated that IL‐1&bgr; regulates phosphorylation of GluA1 and may play an important role in modulation of AMPAR function and synaptic plasticity in the brain.
References
More filters
Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.