Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons.
TL;DR: Investigation of the contribution of GluR2 non-containing AMPA receptor to lead-induced neurotoxic events indicates that Ca2+-permeable AMPA receptors resulting from GLUR2 decrease may be involved in lead- induced neurotoxicity.
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Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons.
Filip Maciąg,Łukasz Majewski,Paweł M. Boguszewski,Rishikesh Kumar Gupta,Iga Wasilewska,Bartosz Wojtaś,Jacek Kuznicki +6 more
TL;DR: The phenotype that was observed in female mice suggests that ORAI1 overexpression may affect neuronal activity in a sex-dependent manner, and this article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
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Auxiliary Proteins are the Predominant Determinants of Differential Efficacy of Clinical Candidates Acting as AMPA Receptor Positive Allosteric Modulators.
TL;DR: It is concluded that compounds that discriminate between AMPARs complexed with distinct TARPs, and particularly those with lower stargazin/γ2 efficacy such as BIIB104, could act as viable procognitive therapeutics.
Journal ArticleDOI
Constraint-induced movement therapy improves functional recovery after ischemic stroke and its impacts on synaptic plasticity in sensorimotor cortex and hippocampus.
TL;DR: Investigation of the impact of CIMT on synaptic plasticity in ipsilateral and contralateral brain of rats following stroke suggests that the dendrites and dendritic spines are damaged to varying degrees in bilateral sensorimotor cortex and hippocampus after acute stroke.
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Mechanisms underlying the synaptic trafficking of the glutamate delta receptor GluD1
Wucheng Tao,Chenxue Ma,Michael A. Bemben,Kathy H. Li,Alma L. Burlingame,Mingjie Zhang,Roger A. Nicoll +6 more
TL;DR: This work utilizes chimeric constructs, in which the ligand-binding domain of GluD1 is replaced by that of GLUK1, to examine its synaptic trafficking and plasticity, and finds that mutation of threonine T923 to an alanine disrupted synaptic trafficking.
References
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The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.